Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.49 |
| ▸ | ITGAL | P20701 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | JAK3 | P52333 | 6/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27801034 | 0.82 | ITGB2 (0.55) | ITGB2ICAM1ITGALJAK2JAK3 | |
| SCHEMBL21434097 | 0.78 | ITGB2 (0.56) | ITGB2ICAM1ITGALJAK2JAK3 | |
| SCHEMBL4966191 | 0.70 | GAK (0.49) | FPR2SCN9ACDK9HPGDPOLB | |
| SCHEMBL27800969 | 0.68 | DPP4 (0.47) | ITGB2ICAM1ITGALDPP4 | |
| SCHEMBL2938519 | 0.67 | JAK2 (0.79) | ITGB2ICAM1ITGALJAK2JAK3 | |
| SCHEMBL2446468 | 0.67 | RAB9A (0.50) | MAPTPOLB | |
| SCHEMBL21211009 | 0.67 | JAK2 (0.49) | ITGB2ICAM1ITGALJAK2JAK3 | |
| SCHEMBL30027591 | 0.67 | JAK2 (0.49) | ITGB2ICAM1ITGALJAK2JAK3 | |
| SCHEMBL27873347 | 0.67 | CDK9 (0.52) | ITGB2ICAM1ITGALFPR2SCN9A | |
| SCHEMBL27856595 | 0.67 | CDK9 (0.52) | ITGB2ICAM1ITGALFPR2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101889004-A | Protein kinase inhibitors | INGENIUM PHARMACEUTICALS GMBH | 2010-11-17 | — | — | CN | disclosed |