Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458568 | 0.81 | RAB9A (0.49) | KDM4ESMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL3374110 | 0.79 | KDM4E (0.62) | KDM4ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL30925390 | 0.76 | L3MBTL1 (0.42) | KDM4ELMNAALDH1A1KMT2AEGFR | |
| SCHEMBL7736717 | 0.76 | LMNA (0.37) | KDM4ELMNAALDH1A1EGFR | |
| SCHEMBL329598 | 0.72 | KDM4E (0.41) | KDM4ELMNAALDH1A1EGFRHPGD | |
| SCHEMBL637363 | 0.71 | CA1 (0.45) | KDM4ELMNAALDH1A1EGFRMAPK1 | |
| SCHEMBL1667129 | 0.71 | KDM4E (0.75) | KDM4ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL31387787 | 0.71 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2LMNAALDH1A1EGFR | |
| SCHEMBL7372803 | 0.71 | L3MBTL1 (0.41) | KDM4ESMN1; SMN2POLBALDH1A1TSHR | |
| SCHEMBL5135088 | 0.71 | KDM4E (0.60) | KDM4ESMN1; SMN2LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103097526-A | MEK1 mutation conferring resistance to RAF and MEK inhibitors | DANA FARBER CANCER INST INC | 2013-05-08 | — | — | CN | disclosed |
| CN-103038364-A | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy | DANA FARBER CANCER INST INC | 2013-04-10 | — | — | CN | disclosed |