Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.67 |
| ▸ | CA12 | O43570 | 5/20 | 0.66 |
| ▸ | CA4 | P22748 | 5/20 | 0.66 |
| ▸ | CA9 | Q16790 | 5/20 | 0.66 |
| ▸ | CA1 | P00915 | 2/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | CA6 | P23280 | 3/20 | 0.61 |
| ▸ | CA5A | P35218 | 3/20 | 0.61 |
| ▸ | CA7 | P43166 | 3/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.61 |
| ▸ | TTR | P02766 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319077 | 1.00 | MET (0.67) | METCA12CA4CA9CA1 | |
| Potassium Ion SCHEMBL6385906 | 0.99 | MET (0.66) | METCA12CA4CA9CA1 | |
| SCHEMBL13242536 | 0.99 | MET (0.66) | METCA12CA4CA9CA1 | |
| SCHEMBL13242531 | 0.99 | MET (0.66) | METCA12CA4CA9CA1 | |
| SCHEMBL6385902 | 0.99 | MET (0.66) | METCA12CA4CA9CA1 | |
| SCHEMBL13242532 | 0.98 | MET (0.67) | METCA12CA4CA9CA1 | |
| SCHEMBL2991870 | 0.94 | CA12 (0.70) | METCA12CA4CA9CA1 | |
| SCHEMBL2991875 | 0.94 | CA12 (0.70) | METCA12CA4CA9CA1 | |
| SCHEMBL1321817 | 0.93 | MET (0.69) | METCA12CA4CA9CA1 | |
| SCHEMBL13242533 | 0.93 | MET (0.69) | METCA12CA4CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179192-A1 | USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN | NICOX S.A. (FR) | 2010-07-15 | — | — | US | claimed |
| EP-2167070-A1 | USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN | Nicox S.A. (FR) | 2010-03-31 | — | — | EP | claimed |
| WO-2009007230-A1 | USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN | NICOX S.A. (FR) | 2009-01-15 | — | — | WO | claimed |
| US-7812039-B2 | analgesic drug for treating neuropathic pain is selected from gabapentine, norvaline, pregabaline, (S)3-isobutylGABA, arginine, thiocitrulline, agmantine, vigabatrin etc. and a NO donar drugs belonging to the classes of aspirin, ibuprofen, paracetamol, naproxen, diclofenac or flurbiprofen | NICOX S.A. (FR) | 2010-10-12 | — | — | US | disclosed |
| US-20100217028-A1 | PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF | NICOX S.A. (FR) | 2010-08-26 | — | — | US | disclosed |
| US-7759392-B2 | Pharmaceutical compounds | NICOX S.A. (FR) | 2010-07-20 | — | — | US | disclosed |
| US-20100179192-A1 | USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN | NICOX S.A. (FR) | 2010-07-15 | — | — | US | disclosed |
| US-20100179192-A1 | USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN | NICOX S.A. (FR) | 2010-07-15 | — | — | US | disclosed |
| US-7745496-B2 | Process for preparing halogenoalkylnitrates | NICOX S.A. (FR) | 2010-06-29 | — | — | US | disclosed |
| US-7723382-B2 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof | NICOX S.A. (FR) | 2010-05-25 | — | — | US | disclosed |
| US-7696230-B2 | Drugs for chronic pains | NICOX S.A. (FR) | 2010-04-13 | — | — | US | disclosed |
| EP-1814840-A1 | PROCESS FOR PREPARING HALOGENOALKYLNITRATES | NicOx S.A. (FR) | 2007-08-08 | — | — | EP | disclosed |
| US-20070161576-A1 | Drugs for chronic pains | NICOX S.A. | 2007-07-12 | — | — | US | disclosed |
| US-20070112194-A1 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof | NICOX S.A. (FR) | 2007-05-17 | — | — | US | disclosed |
| US-7199141-B2 | Drugs for chronic pains | NICOX S.A. (FR) | 2007-04-03 | — | — | US | disclosed |
| US-7186753-B1 | Pharmaceutical compounds | NICOX S.A. (FR) | 2007-03-06 | — | — | US | disclosed |
| WO-2006056535-A1 | PROCESS FOR PREPARING HALOGENOALKYLNITRATES | NICOX S.A. (FR) | 2006-06-01 | — | — | WO | disclosed |
| EP-1537070-A1 | PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF | Nicox S.A. (FR) | 2005-06-08 | — | — | EP | disclosed |
| US-20040171682-A1 | Drugs for chronic pains | NICOX S.A. (FR) | 2004-09-02 | — | — | US | disclosed |
| WO-2004020385-A1 | PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF | NICOX S.A. (FR) | 2004-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171682-A1 | Drugs for chronic pains | OPRD1, OPRK1, OPRL1 | MET 3745/4885CA12 2192/4885CA4 1108/4885 |
| US-20070161576-A1 | Drugs for chronic pains | OPRD1, OPRL1, OPRK1 | MET 3070/4885CA12 2157/4885CA4 937/4885 |
| US-20100217028-A1 | PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF | CYP2A13, CYP3A43, POR | MET 585/4885CA12 517/4885CA4 481/4885 |
| US-20100179192-A1 | USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN | NOS1, NOS2, NOS3 | MET 4453/4885CA12 3464/4885CA4 2043/4885 |
| US-20070112194-A1 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof | CYP2A13, CYP3A43, POR | MET 585/4885CA12 517/4885CA4 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.