Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883109 | 0.91 | CDC7 (0.48) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2883557 | 0.89 | PTPN11 (0.47) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2881201 | 0.89 | PTPN11 (0.52) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2886405 | 0.88 | PTPN11 (0.45) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2881225 | 0.88 | MAPT (0.41) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2886835 | 0.88 | PTPN11 (0.44) | PTPN11ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL2887022 | 0.88 | PTPN11 (0.46) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2887105 | 0.88 | LMNA (0.52) | PTPN11ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL2881257 | 0.87 | TRPM8 (0.49) | PTPN11KDM4EMAPTPOLBSMN1; SMN2 | |
| SCHEMBL2880605 | 0.87 | ALDH1A1 (0.41) | PTPN11ALDH1A1KDM4EMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124489-B1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3124489-A1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | Fibrogen, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |
| US-7803807-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7696223-B2 | [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) | FIBROGEN, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| US-7687514-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICALS CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-20100048600-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MSD K.K. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| US-7105526-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICALS CO., LTD. (JP) | 2006-09-12 | — | — | US | disclosed |
| US-20040054177-A1 | Novel benzimidazole derivatives | MSD K.K. (JP) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040054177-A1 | Novel benzimidazole derivatives | OPRM1, OPRK1, HTR7 | PTPN11 3621/4885ALDH1A1 2587/4885KDM4E 1923/4885 |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | PTPN11 1671/4885ALDH1A1 1047/4885KDM4E 754/4885 |
| US-20100048600-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | NPY4R, NPY5R, NPY1R | PTPN11 3020/4885ALDH1A1 2759/4885KDM4E 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.