Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28826079 | 0.77 | KDM4E (0.46) | L3MBTL1KMT2APKMALDH1A1KDM4E | |
| SCHEMBL26631768 | 0.73 | TDP1 (0.54) | L3MBTL1TDP1ATMALDH1A1KDM4E | |
| SCHEMBL14560448 | 0.72 | EGFR (0.50) | L3MBTL1TDP1ATMALDH1A1KDM4E | |
| SCHEMBL7263191 | 0.72 | NPC1 (0.53) | L3MBTL1TDP1ATMKMT2AALDH1A1 | |
| SCHEMBL1092376 | 0.71 | L3MBTL1 (0.55) | L3MBTL1TDP1ATMALDH1A1KDM4E | |
| SCHEMBL15959922 | 0.71 | POLB (0.53) | L3MBTL1TDP1KMT2AALDH1A1KDM4E | |
| SCHEMBL14560411 | 0.70 | ATM (0.43) | L3MBTL1TDP1ATMKMT2AALDH1A1 | |
| SCHEMBL28165403 | 0.69 | L3MBTL1 (0.54) | L3MBTL1TDP1ATMALDH1A1KDM4E | |
| SCHEMBL14222653 | 0.69 | L3MBTL1 (0.54) | L3MBTL1TDP1ATMALDH1A1KDM4E | |
| SCHEMBL28236134 | 0.69 | L3MBTL1 (0.54) | L3MBTL1TDP1ATMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981275-B | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-114981275-A | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2022-08-30 | — | — | CN | disclosed |