Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.52 |
| ▸ | HSD17B14 | Q9BPX1 | 3/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 4/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756842 | 0.82 | NPC1 (0.60) | NPC1SMN1; SMN2RAB9ACES2CES1 | |
| SCHEMBL2882824 | 0.78 | VNN1 (0.42) | NPC1SMN1; SMN2RAB9AKCNQ3KCNQ2 | |
| SCHEMBL12975496 | 0.76 | VNN1 (0.56) | KCNQ3KCNQ2HSD17B14HSD17B1HSD17B2 | |
| SCHEMBL7493215 | 0.75 | POLB (0.52) | NPC1SMN1; SMN2RAB9AALDH1A1GAA | |
| SCHEMBL12975442 | 0.74 | CES2 (0.47) | KCNQ3KCNQ2HSD17B14HSD17B1HSD17B2 | |
| SCHEMBL7967901 | 0.73 | CES2 (0.73) | RAB9AKCNQ3KCNQ2HSD17B14HSD17B1 | |
| SCHEMBL1534957 | 0.73 | VNN1 (0.49) | KCNQ3KCNQ2HSD17B14HSD17B1HSD17B2 | |
| SCHEMBL13991056 | 0.71 | CES2 (0.57) | NPC1SMN1; SMN2RAB9AKCNQ3KCNQ2 | |
| SCHEMBL8845773 | 0.71 | ALDH1A1 (0.64) | SMN1; SMN2RAB9AHSD17B1HSD17B2CES2 | |
| SCHEMBL5213301 | 0.69 | KCNQ3 (1.00) | NPC1SMN1; SMN2RAB9AKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MSD K.K. (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MSD K.K. (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MSD K.K. (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20090247560-A1 | Diaryl ketimine derivative | BANYU PHARMACEUTICAL CO., LTD. | 2009-10-01 | — | — | US | disclosed |
| US-20090247560-A1 | Diaryl ketimine derivative | BANYU PHARMACEUTICAL CO., LTD. | 2009-10-01 | — | — | US | disclosed |
| US-20090247560-A1 | Diaryl ketimine derivative | BANYU PHARMACEUTICAL CO., LTD. | 2009-10-01 | — | — | US | disclosed |
| EP-2072519-A1 | DIARYL KETIMINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-06-24 | — | — | EP | disclosed |
| EP-2072519-A1 | DIARYL KETIMINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MC1R, MCHR1, MCHR2 | NPC1 825/4885SMN1; SMN2 4128/4885RAB9A 236/4885 |
| US-20090247560-A1 | Diaryl ketimine derivative | NR0B2, NR2C2, NR3C2 | NPC1 1131/4885SMN1; SMN2 3309/4885RAB9A 2541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.