SCHEMBL28840504

SCHEMBL28840504

O=[N+]([O-])c1cc(C(F)(F)F)ccc1C(Cl)(Cl)Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
CYP3A4 P08684 2/20 0.56
HPGD P15428 1/20 0.56
ALOX15 P16050 1/20 0.56
TSHR P16473 1/20 0.56
HIF1A Q16665 1/20 0.56
TXNRD1 Q16881 1/20 0.56
TXNRD3 Q86VQ6 1/20 0.56
TXNRD2 Q9NNW7 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
MAPT P10636 4/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAPK1 P28482 3/20 0.48
EPAS1 Q99814 1/20 0.47
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1995690 0.87 ALDH1A1 (0.56) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL29398386 0.87 ALDH1A1 (0.56) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL7039417 0.83 ALDH1A1 (0.51) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL29942185 0.80 ALDH1A1 (0.60) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL7240751 0.80 ALDH1A1 (0.60) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL140068 0.79 ALDH1A1 (0.65) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL8187684 0.79 ALDH1A1 (0.55) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL28090702 0.78 MAPK1 (0.47) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL4747577 0.77 TDP1 (0.55) ALDH1A1HPGDTSHRHIF1ATXNRD1
SCHEMBL2158306 0.77 ALDH1A1 (0.56) ALDH1A1CYP3A4HPGDALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114907232-B Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile 青岛和兴精细化学有限公司 2024-02-23 CN claimed
CN-114907232-A Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile 青岛和兴精细化学有限公司 2022-08-16 CN claimed
CN-114907232-B Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile 青岛和兴精细化学有限公司 2024-02-23 CN disclosed
CN-114907232-B Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile 青岛和兴精细化学有限公司 2024-02-23 CN disclosed
CN-114907232-A Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile 青岛和兴精细化学有限公司 2022-08-16 CN disclosed
CN-114907232-A Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile 青岛和兴精细化学有限公司 2022-08-16 CN disclosed