SCHEMBL28849419

SCHEMBL28849419

O[C@]1(c2ccccc2)CCCC[C@@H]1Cc1ccncc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.58
SLC6A2 P23975 9/20 0.42
SLC6A4 P31645 9/20 0.42
OPRM1 P35372 8/20 0.42
OPRD1 P41143 3/20 0.42
OPRK1 P41145 3/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
SLC6A9 P48067 1/20 0.40
SLC22A1 O15245 3/20 0.40
CHRM2 P08172 1/20 0.40
CHRM1 P11229 1/20 0.40
NPY1R P25929 1/20 0.40
HTT P42858 1/20 0.40
NPY2R P49146 1/20 0.40
CNR2 P34972 2/20 0.39
CNR1 P21554 1/20 0.39
CYP19A1 P11511 1/20 0.39
LMNA P02545 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29950758 0.85 TRPA1 (0.45) TRPA1SLC6A2SLC6A4OPRM1OPRD1
SCHEMBL28849444 0.85 TRPA1 (0.45) TRPA1SLC6A2SLC6A4OPRM1OPRD1
SCHEMBL28849438 0.80 MAPT (0.42) TRPA1SLC6A2SLC6A4OPRM1OPRD1
SCHEMBL898940 0.77 SLC6A2 (0.49) SLC6A2SLC6A4OPRM1OPRD1OPRK1
SCHEMBL898941 0.77 SLC6A2 (0.49) SLC6A2SLC6A4OPRM1OPRD1OPRK1
SCHEMBL4989694 0.76 SLC6A2 (0.51) SLC6A2SLC6A4OPRM1OPRD1OPRK1
SCHEMBL28849421 0.75 TRPA1 (0.42) TRPA1SLC6A2SLC6A4OPRM1OPRD1
SCHEMBL7595748 0.74 OPRM1 (0.47) SLC6A2SLC6A4OPRM1OPRD1OPRK1
SCHEMBL5880550 0.73 SLC6A4 (0.62) TRPA1SLC6A2SLC6A4OPRM1OPRD1
SCHEMBL6936956 0.73 SLC6A2 (0.49) TRPA1SLC6A2SLC6A4OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108875-B Nitrogen-containing heteroarene chiral cyclic alcohol constructed by asymmetric catalysis of visible light, and preparation method and application thereof 河南师范大学 2023-07-04 CN disclosed
CN-115108875-A Nitrogen-containing heteroarene chiral cyclic alcohol constructed by visible light asymmetric catalysis, and preparation method and application thereof 河南师范大学 2022-09-27 CN disclosed