Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | AOC2 | O75106 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17942537 | 0.82 | TGFBR1 (0.59) | CACNA1BTGFBR1GPR119 | |
| SCHEMBL28045809 | 0.81 | SLC2A1 (0.49) | ALDH1A1 | |
| SCHEMBL17942381 | 0.79 | CACNA1B (0.48) | GAACACNA1BAOC2MEN1KMT2A | |
| SCHEMBL27702431 | 0.78 | KCNH2 (0.46) | GAATGFBR1TRPV4CNR1KCNH2 | |
| SCHEMBL15103526 | 0.76 | AOC2 (0.42) | CACNA1BAOC2MEN1KMT2AGPR119 | |
| SCHEMBL28184649 | 0.76 | AOC2 (0.37) | CACNA1BAOC2HTR2AHTR2CALDH1A1 | |
| SCHEMBL27968804 | 0.75 | HSD11B1 (0.56) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL27905942 | 0.75 | INPP5A (0.35) | AOC2GPR119 | |
| SCHEMBL28024325 | 0.75 | GPR119 (0.33) | AOC2ALDH1A1GPR119 | |
| SCHEMBL27579513 | 0.75 | CARM1 (0.56) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428719-A | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2017-12-01 | — | — | CN | disclosed |