Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356299 | 0.92 | — | — | |
| SCHEMBL13226373 | 0.92 | — | — | |
| SCHEMBL6823815 | 0.81 | CYP1A2 (0.32) | CYP1A2 | |
| SCHEMBL8571024 | 0.70 | ADH1A (0.32) | CYP1A2 | |
| SCHEMBL23219663 | 0.70 | CHRNB4 (0.33) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL9874179 | 0.70 | SIGMAR1 (0.34) | — | |
| SCHEMBL21884120 | 0.69 | CYP1A2 (0.31) | CYP1A2 | |
| SCHEMBL3110957 | 0.69 | — | — | |
| SCHEMBL21760080 | 0.69 | — | — | |
| SCHEMBL11418167 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174540-A1 | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| US-20210179627-A1 | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2021-06-17 | — | — | US | disclosed |
| WO-2021063346-A1 | KRAS G12C INHIBITOR AND APPLICATION THEREOF | 上海迪诺医药科技有限公司 | 2021-04-08 | — | — | WO | disclosed |
| US-20200399280-A1 | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2020-12-24 | — | — | US | disclosed |
| US-10807989-B2 | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | Grünenthal GmbH (DE) | 2020-10-20 | — | — | US | disclosed |
| US-20180282341-A1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2018-10-04 | — | — | US | disclosed |
| US-7709475-B2 | 5-[2-(cyclohexyloxy)-6-methyl-4-pyrimidinyl]-2-[5-(4-methyl-1-piperazinyl)methyl-2-pyrazinyl]amino-1,3-thiazole; anticarcinogenic agent; G1 phase in cell cycle; great selectivity | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-04 | — | — | US | disclosed |
| US-20080081811-A1 | Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton | BANYU PHARMACEUTICAL CO., LTD (JP) | 2008-04-03 | — | — | US | disclosed |
| CN-1956982-A | Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton | BANYU PHARMA CO LTD (JP) | 2007-05-02 | — | — | CN | disclosed |
| EP-1754706-A1 | SELECTIVE INHIBITORS AGAINST Cdk4 AND Cdk6 HAVING AMINOTHIAZOLE SKELETON | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-02-21 | — | — | EP | disclosed |
| US-20060252926-A1 | Process for the preparation of pregnanes | SICOR, INC. | 2006-11-09 | — | — | US | disclosed |
| EP-1474435-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA FLUORINATED PREGNANES | SICOR INC (US) | 2006-02-22 | — | — | EP | disclosed |
| EP-1474435-A1 | PROCESS FOR THE PREPARATION OF PREGNANES | Sicor Inc. (US) | 2004-11-10 | — | — | EP | disclosed |
| WO-2004052911-A1 | PROCESS FOR THE PREPARATION OF PREGNANES | SICOR INC. (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081811-A1 | Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton | CDK4, CDK6, CDK3 | CYP1A2 1792/4885MAP4K4 176/4885CHRNB2 4442/4885 |
| US-20200399280-A1 | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, PKD2 | CYP1A2 573/4885MAP4K4 1711/4885CHRNB2 391/4885 |
| US-20180282341-A1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, PKD2 | CYP1A2 573/4885MAP4K4 1711/4885CHRNB2 391/4885 |
| US-20060252926-A1 | Process for the preparation of pregnanes | CYP17A1, CYP21A2, NR5A1 | CYP1A2 48/4885MAP4K4 976/4885CHRNB2 644/4885 |
| US-10807989-B2 | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | OPRK1, OPRD1, PKD2 | CYP1A2 573/4885MAP4K4 1711/4885CHRNB2 391/4885 |
| US-20210179627-A1 | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, PKD2 | CYP1A2 573/4885MAP4K4 1711/4885CHRNB2 391/4885 |
| US-20230174540-A1 | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, PKD2 | CYP1A2 573/4885MAP4K4 1711/4885CHRNB2 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.