Toluene

Toluene

SCHEMBL28853124

Cc1ccccc1.O=[N+]([O-])c1c(Cl)cccc1Cl

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
TDP1 Q9NUW8 2/20 0.50
HPRT1 P00492 1/20 0.47
TSHR P16473 6/20 0.46
ACHE P22303 3/20 0.46
LMNA P02545 3/20 0.42
ALOX12 P18054 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPT P10636 3/20 0.41
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
XBP1 P17861 1/20 0.41
PAX8 Q06710 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TLR9 Q9NR96 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL670917 0.85 TSHR (0.58) ALDH1A1TDP1TSHRLMNAHSD17B10
Toluene SCHEMBL28103286 0.82 VCAM1 (0.46) TSHRLMNANPC1RAB9ASMN1; SMN2
Phenol SCHEMBL28068525 0.81 GRIN2D (0.46) ALDH1A1TDP1TSHRLMNAMAPT
Toluene SCHEMBL27576042 0.81 HSD17B10 (0.53) ALDH1A1TDP1TSHRLMNAHSD17B10
SCHEMBL541489 0.80 TDP1 (0.72) ALDH1A1TDP1TSHRHSD17B10SMN1; SMN2
Toluene SCHEMBL28299175 0.78 TSHR (0.66) ALDH1A1TDP1HPRT1TSHRACHE
SCHEMBL28285744 0.78 ALDH1A1 (0.50) ALDH1A1TDP1TSHRLMNAHSD17B10
Formic Acid SCHEMBL28829433 0.76 ALDH1A1 (0.48) ALDH1A1TDP1TSHRHPGDGRIN2D
SCHEMBL4583260 0.76 ALDH1A1 (0.53) ALDH1A1TDP1HPRT1TSHRLMNA
SCHEMBL16174808 0.75 MAPT (0.51) ALDH1A1TDP1LMNAMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105189447-B The method for manufacturing nitrobenzene compound 组合化学工业株式会社 2017-12-05 CN disclosed