SCHEMBL28859528

SCHEMBL28859528

[CH2]c1ccc(N2CCCC2)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 1/20 0.47
MAPT P10636 6/20 0.46
L3MBTL1 Q9Y468 6/20 0.46
LMNA P02545 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
ALOX12 P18054 1/20 0.46
ALDH1A1 P00352 6/20 0.45
GFER P55789 1/20 0.45
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
ALOX15 P16050 3/20 0.44
HSD17B10 Q99714 3/20 0.44
TERT O14746 3/20 0.44
GAA P10253 3/20 0.43
HTT P42858 3/20 0.43
S100B P04271 2/20 0.43
PKM P14618 1/20 0.43
MAPK1 P28482 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
KDM4E B2RXH2 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15094133 0.83 LGMN (0.49) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL3587877 0.83 HTR3A (0.50) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL9830834 0.81 ADRB1 (0.68) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL7715055 0.79 ADRB1 (0.66) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL8264511 0.78 MAPT (0.68) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL23843625 0.76 ABCG2 (0.48) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL30228205 0.76 MEN1 (0.69) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL17050470 0.76 LMNA (0.50) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL10277024 0.74 MEN1 (0.46) ADRB1MAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL25596780 0.74 DRD2 (0.50) ADRB1MAPTL3MBTL1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107982266-A Carbamate compounds and its preparation and application 阿比德治疗公司 2018-05-04 CN disclosed