SCHEMBL28873804

SCHEMBL28873804

O=C(O)c1ccc(-c2ccc(C(F)(F)C(F)(F)C(F)F)cc2)cc1C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRB P28702 3/20 0.43
RXRA P19793 2/20 0.43
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
ACLY P53396 3/20 0.40
ACMSD Q8TDX5 3/20 0.40
HNF4A P41235 2/20 0.40
MCL1 Q07820 2/20 0.40
DHFR P00374 1/20 0.40
GFER P55789 1/20 0.40
KMT2A Q03164 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
AKR1C2 P52895 1/20 0.38
AKR1C1 Q04828 1/20 0.38
RXRG P48443 1/20 0.38
KDM1A O60341 2/20 0.37
USP2 O75604 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL873525 0.87 HSD17B10 (0.46) RXRBRXRAKDM4EALDH1A1HPGD
SCHEMBL27770936 0.81 RXRB (0.43) RXRBRXRAKDM4EALDH1A1HPGD
SCHEMBL4890609 0.81 POLB (0.51) KDM4EALDH1A1HPGDHSD17B10MCL1
SCHEMBL29459104 0.79 RXRB (0.46) RXRBRXRAKDM4EALDH1A1HPGD
SCHEMBL346231 0.79 RXRB (0.46) RXRBRXRAKDM4EALDH1A1HPGD
SCHEMBL710222 0.77 KMT2A (0.60) KDM4EALDH1A1HSD17B10ACMSDHNF4A
SCHEMBL29436303 0.77 KMT2A (0.60) KDM4EALDH1A1HSD17B10ACMSDHNF4A
SCHEMBL9550353 0.77 KMT2A (0.60) KDM4EALDH1A1HSD17B10ACMSDHNF4A
SCHEMBL27770934 0.77 KMT2A (0.41) RXRBRXRAKDM4EALDH1A1HSD17B10
SCHEMBL4368256 0.76 SRD5A2 (0.53) RXRBRXRAALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112368108-B Adhesive tape for glass processing 古河电气工业株式会社 2022-11-04 CN disclosed