SCHEMBL28879004

SCHEMBL28879004

COc1cccc2c(-c3ccccc3)cc(C(=O)c3ccccc3)nc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACA Q13085 3/20 0.55
PDE10A Q9Y233 1/20 0.55
ALDH1A1 P00352 1/20 0.50
TNKS O95271 1/20 0.48
TNKS2 Q9H2K2 1/20 0.48
PARP2 Q9UGN5 1/20 0.48
MEN1 O00255 1/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ALOX15 P16050 1/20 0.44
DHODH Q02127 1/20 0.44
GRM2 Q14416 1/20 0.43
HSP90AA1 P07900 1/20 0.43
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43
TUBA3C P0DPH7 1/20 0.43
TUBA1B P68363 1/20 0.43
TUBA4A P68366 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1811192 0.90 PDE10A (0.61) ACACAPDE10AALDH1A1TNKSTNKS2
SCHEMBL6079947 0.87 ACACA (0.55) ACACAPDE10AALDH1A1TNKSTNKS2
SCHEMBL6593342 0.80 TNKS (0.52) ACACAPDE10AALDH1A1TNKSTNKS2
SCHEMBL6080970 0.77 TNKS (0.54) ACACAPDE10ATNKSTNKS2PARP2
SCHEMBL28879046 0.76 ALDH1A1 (0.71) ACACAALDH1A1MEN1NPC1RAB9A
SCHEMBL16294796 0.75 ACACA (0.65) ACACAPDE10AALDH1A1TNKSTNKS2
SCHEMBL28879012 0.75 ALDH1A1 (0.55) ACACAALDH1A1MEN1RAB9AKMT2A
SCHEMBL6591002 0.75 KDM4E (0.51) ACACAPDE10AALDH1A1TNKSTNKS2
SCHEMBL28231524 0.74 ALOX15 (0.50) ACACAPDE10AALDH1A1ALOX15DHODH
SCHEMBL6596151 0.74 GPR35 (0.56) PDE10AALDH1A1TNKSTNKS2PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114249689-A Synthetic method of benzoyl quinoline compound 温州大学 2022-03-29 CN disclosed