Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28880329 | 0.84 | LPAR1 (0.37) | NPC1RAB9AMEN1KMT2ACXCL8 | |
| SCHEMBL29163982 | 0.81 | TAS2R14 (0.39) | LMNALPAR1SMN1; SMN2 | |
| SCHEMBL30292599 | 0.80 | SMN1; SMN2 (0.39) | NPC1RAB9ACXCL8NLRP3ALDH1A1 | |
| SCHEMBL28880407 | 0.80 | SMN1; SMN2 (0.39) | NPC1RAB9ACXCL8NLRP3ALDH1A1 | |
| SCHEMBL28880362 | 0.78 | SLC6A3 (0.35) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL28880383 | 0.78 | HTT (0.35) | MEN1KMT2ACXCL8HTTALDH1A1 | |
| SCHEMBL28880382 | 0.78 | HTT (0.35) | MEN1KMT2ACXCL8HTTALDH1A1 | |
| SCHEMBL25222548 | 0.76 | KMT2A (0.47) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL22497586 | 0.74 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL17465167 | 0.74 | HCAR2 (0.50) | MEN1KMT2AHTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117999263-A | SOS1 inhibitor with pyrido six-membered ring structure | 上海海和药物研究开发股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-115135315-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2022-09-30 | — | — | CN | disclosed |