Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889342 | 0.90 | OPRM1 (0.40) | PHGDHALDH1A1KMT2ASMN1; SMN2ADRB2 | |
| SCHEMBL29941839 | 0.90 | PHGDH (0.41) | PHGDHALDH1A1KMT2AADRB2MEN1 | |
| SCHEMBL28889186 | 0.84 | MEN1 (0.44) | PHGDHALDH1A1KMT2ASMN1; SMN2ADRB2 | |
| SCHEMBL28889291 | 0.82 | ADRB2 (0.39) | PHGDHALDH1A1KMT2ASMN1; SMN2ADRB2 | |
| SCHEMBL29893566 | 0.82 | ADRB2 (0.39) | PHGDHALDH1A1KMT2ASMN1; SMN2ADRB2 | |
| SCHEMBL29942056 | 0.81 | ALDH1A1 (0.43) | ALDH1A1KMT2ASMN1; SMN2ADRB2MEN1 | |
| SCHEMBL28889200 | 0.80 | ADRB2 (0.41) | ALDH1A1KMT2ASMN1; SMN2ADRB2MEN1 | |
| SCHEMBL29941818 | 0.80 | HDAC4 (0.41) | PHGDHALDH1A1KMT2ASMN1; SMN2ADRB2 | |
| SCHEMBL28889196 | 0.79 | TACR1 (0.43) | ALDH1A1KMT2ASMN1; SMN2ADRB2MEN1 | |
| SCHEMBL28889226 | 0.79 | AURKA (0.42) | PHGDHALDH1A1KMT2AADRB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |