Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889177 | 0.85 | HDAC4 (0.40) | PHGDHLMNAKMT2ANPSR1PDE4B | |
| SCHEMBL28889234 | 0.84 | PDE4B (0.38) | PHGDHLMNAKMT2ANPSR1PDE4B | |
| SCHEMBL29893652 | 0.84 | PDE4B (0.38) | PHGDHLMNAKMT2ANPSR1PDE4B | |
| SCHEMBL29942052 | 0.83 | KMT2A (0.40) | HCRTR1HCRTR2PHGDHSOS1LMNA | |
| SCHEMBL28889290 | 0.82 | LMNA (0.40) | PHGDHLMNAKMT2ANPSR1PDE4B | |
| SCHEMBL28889330 | 0.82 | ALDH1A1 (0.44) | PHGDHLMNAKMT2ANPSR1ALDH1A1 | |
| SCHEMBL28889338 | 0.81 | LMNA (0.41) | HCRTR1PHGDHLMNAKMT2ANPSR1 | |
| SCHEMBL29893626 | 0.80 | LMNA (0.41) | HCRTR1PHGDHLMNAKMT2ANPSR1 | |
| SCHEMBL28889248 | 0.80 | LMNA (0.41) | HCRTR1PHGDHLMNAKMT2ANPSR1 | |
| SCHEMBL28889357 | 0.80 | ALDH1A1 (0.39) | PHGDHLMNAKMT2ANPSR1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |