Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.56 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.56 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366240 | 0.83 | KDM4E (0.52) | KDM4EKMT2ALMNAMEN1TSHR | |
| SCHEMBL22965215 | 0.82 | LMNA (0.60) | KDM4EKMT2ALMNATSHRTP53 | |
| SCHEMBL540852 | 0.81 | LMNA (0.59) | KDM4EKMT2ALMNATSHRTP53 | |
| SCHEMBL1520208 | 0.79 | KDM4E (0.57) | KDM4EKMT2ALMNAMEN1TSHR | |
| SCHEMBL28516010 | 0.78 | LMNA (0.62) | KDM4EKMT2ALMNATSHRTP53 | |
| SCHEMBL5813721 | 0.77 | FABP4 (0.55) | KDM4EKMT2ALMNAMEN1HSD17B10 | |
| SCHEMBL23779995 | 0.76 | KDM4E (0.60) | KDM4EKMT2ALMNAMEN1TP53 | |
| SCHEMBL9697129 | 0.76 | KDM4E (0.57) | KDM4EKMT2ALMNAMEN1TSHR | |
| SCHEMBL6325602 | 0.76 | SMN1; SMN2 (0.70) | KDM4EKMT2AMEN1TSHRNPSR1 | |
| SCHEMBL540895 | 0.75 | TP53 (0.65) | KDM4ELMNATP53GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979660-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-107849023-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-111269221-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-06-12 | — | — | CN | disclosed |