Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5110074 | 0.87 | KCNA5 (0.48) | TRPV1KCNN4KCNA5PDCD1CD274 | |
| SCHEMBL7160604 | 0.87 | KDM4E (0.48) | TRPV1KCNN4KCNA5PDK1KDM4E | |
| SCHEMBL30832971 | 0.87 | KDM4E (0.48) | TRPV1KCNN4KCNA5PDK1KDM4E | |
| SCHEMBL17455924 | 0.86 | TRPV1 (0.46) | TRPV1KCNN4KCNA5PDK1KDM4E | |
| SCHEMBL5144683 | 0.82 | CYP2A6 (0.58) | KCNN4KCNA5PDK1PTGS2KDM4E | |
| SCHEMBL3719145 | 0.82 | TRPV1 (0.47) | TRPV1PDK1KDM4EALDH1A1USP2 | |
| SCHEMBL4049174 | 0.82 | TRPV1 (0.47) | TRPV1KCNN4KCNA5PDK1KDM4E | |
| SCHEMBL21973538 | 0.82 | PTGS1 (0.46) | TRPV1KCNN4KCNA5PTGS1PTGS2 | |
| SCHEMBL13869175 | 0.82 | PTGS1 (0.46) | TRPV1KCNN4KCNA5PTGS1PTGS2 | |
| SCHEMBL5616194 | 0.82 | DPP4 (0.59) | KCNN4KCNA5PTGS1PTGS2LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150266864-A1 | HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN | CRISTÁLIA PRODUTOS QUÍMICOS FARMACÊUTICOS LTDA (BR) | 2015-09-24 | — | — | US | disclosed |
| EP-2098517-B1 | NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE | MSD KK (JP) | 2013-12-18 | — | — | EP | disclosed |
| US-8367708-B2 | Phenyl-isoxazol-3-ol derivative | MSD K.K. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20100130559-A1 | NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-2098517-A1 | NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-09-09 | — | — | EP | disclosed |
| US-7342116-B2 | Process for producing heterocyclic aldehyde | KOEI CHEMICAL CO., LTD. (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20050124807-A1 | oxidation of a hetero alcohol in presence od an 2,2,6,6-teraalkylpiperidin-1-oxy comound | KOEI CHEMICAL CO., LTD. (JP) | 2005-06-09 | — | — | US | disclosed |
| EP-0946570-B1 | PROCESS FOR THE PREPARATION OF AN ORGANOZINC REAGENT | AVECIA LTD (GB) | 2002-06-12 | — | — | EP | disclosed |
| US-6258967-B1 | REACTING ZINC HALIDE WITH ORGAOMETALLIC COMPOUNDS | ZENECA LIMITED (GB) | 2001-07-10 | — | — | US | disclosed |
| EP-0946570-A1 | PROCESS FOR THE PREPARATION OF AN ORGANOZINC REAGENT | ZENECA LIMITED (GB) | 1999-10-06 | — | — | EP | disclosed |
| EP-0291673-B1 | TETRAHYDROPYRIDINE OXIMES, A PROCESS FOR THEIR PREPARATION AND USE THEREOF AS CHOLINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5106858-A | For disfunction of heart, brain, lung or kidney | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0234729-B1 | QUINONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-5073561-A | N-substituted-pyridinyl oximes | WARNER-LAMBERT COMPANY (US) | 1991-12-17 | — | — | US | disclosed |
| US-4985447-A | USEFUL FOR TREATMENT AND PREVENTION OF DISEASES DUE TO DYSFUNCTION OF HEART, BRAIN, LUNG AND KIDNEY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| US-4929734-A | ANTIINFLAMMATORY AGENTS, ANTIDEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| US-4798841-A | COGNITION ACTIVATORS, ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1989-01-17 | — | — | US | disclosed |
| EP-0291673-A1 | Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-11-23 | — | — | EP | disclosed |
| US-4710508-A | ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0234729-A2 | Quinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124807-A1 | oxidation of a hetero alcohol in presence od an 2,2,6,6-teraalkylpiperidin-1-oxy comound | ADH1C, ADH1A, AOX1 | TRPV1 3183/4885KCNN4 1236/4885KCNA5 2665/4885 |
| US-20150266864-A1 | HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN | TRPV1, AP1G1, INA | TRPV1 1/4885KCNN4 155/4885KCNA5 439/4885 |
| US-20100130559-A1 | NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE | GPR119, FFAR3, FFAR2 | TRPV1 126/4885KCNN4 712/4885KCNA5 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.