Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553753 | 0.83 | SMN1; SMN2 (0.50) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL32666095 | 0.81 | SMN1; SMN2 (0.51) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL31457912 | 0.79 | NPC1 (0.58) | KMT2ASMN1; SMN2MEN1NPSR1NPC1 | |
| SCHEMBL2678410 | 0.78 | SMN1; SMN2 (0.51) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL13313066 | 0.75 | GAA (0.51) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL1578826 | 0.74 | ALDH1A1 (0.78) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL6882525 | 0.73 | ALDH1A1 (0.81) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL28541306 | 0.73 | KDM4E (0.43) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL11480252 | 0.73 | ALDH1A1 (0.81) | KMT2ASMN1; SMN2MEN1LMNANPSR1 | |
| SCHEMBL9382818 | 0.72 | NAAA (0.50) | KMT2ASMN1; SMN2MEN1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114514233-A | Fluorescent probes for monoacylglycerol lipases (MAGL) | 豪夫迈·罗氏有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-111936503-A | Oxazin monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2020-11-13 | — | — | CN | disclosed |