Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 12/20 | 0.42 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | GIPR | P48546 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.38 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29473791 | 1.00 | RXRA (0.46) | RXRARXRBRXRGEZH2EZH1 | |
| SCHEMBL28601010 | 0.91 | EZH2 (0.45) | RXRAEZH2EZH1NPC1RAB9A | |
| SCHEMBL29473806 | 0.88 | EZH2 (0.43) | EZH2EZH1NPC1RAB9A | |
| SCHEMBL28595709 | 0.85 | LSS (0.46) | EZH2EZH1PARP1EPHX2 | |
| SCHEMBL28598243 | 0.83 | CCR5 (0.50) | EZH2PARP1EPHX2NPC1RAB9A | |
| SCHEMBL28601006 | 0.83 | EPHX2 (0.49) | EZH2EZH1EPHX2 | |
| SCHEMBL28598409 | 0.82 | MMP13 (0.45) | EZH2EPHX2NPC1RAB9A | |
| SCHEMBL28613717 | 0.82 | SMN1; SMN2 (0.52) | EZH2EZH1 | |
| SCHEMBL29473822 | 0.82 | SMN1; SMN2 (0.52) | EZH2EZH1 | |
| SCHEMBL28609837 | 0.80 | EZH2 (0.48) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045494-B | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2022-04-26 | — | — | CN | disclosed |
| CN-113045494-A | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2021-06-29 | — | — | CN | disclosed |