Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542639 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1ALDH1A1ADAM17TNF | |
| SCHEMBL29152366 | 0.77 | KMT2A (0.47) | SMN1; SMN2CA2ALDH1A1DAOKDM4E | |
| SCHEMBL29152363 | 0.77 | KMT2A (0.47) | SMN1; SMN2CA2ALDH1A1DAOKDM4E | |
| SCHEMBL29845495 | 0.77 | KMT2A (0.47) | SMN1; SMN2CA2ALDH1A1DAOKDM4E | |
| SCHEMBL11630509 | 0.76 | CA2 (0.42) | CA2ALDH1A1DAOKDM4EATM | |
| SCHEMBL9422803 | 0.76 | ADAMTS5 (0.46) | SMN1; SMN2NPSR1ALDH1A1ADAM17DAO | |
| SCHEMBL7104749 | 0.76 | ADAMTS5 (0.46) | SMN1; SMN2NPSR1ALDH1A1ADAM17DAO | |
| SCHEMBL1132913 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2NPSR1ALDH1A1ADAM17DAO | |
| SCHEMBL7097777 | 0.73 | ALDH1A1 (0.60) | SMN1; SMN2NPSR1ALDH1A1ADAM17MMP2 | |
| SCHEMBL15972776 | 0.73 | ALDH1A1 (0.60) | SMN1; SMN2NPSR1ALDH1A1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102911072-B | Method for preparing methyldopa by directly hydrolyzing 5-methyl-5-(3,4-dimethoxybenzyl)hydantoin with acid | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2014-12-24 | — | — | CN | disclosed |
| CN-102911072-B | Method for preparing methyldopa by directly hydrolyzing 5-methyl-5-(3,4-dimethoxybenzyl)hydantoin with acid | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2014-12-24 | — | — | CN | disclosed |
| CN-102775319-B | Method for preparing methyldopa through microwave basic hydrolysis 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2014-04-16 | — | — | CN | disclosed |
| CN-102775319-B | Method for preparing methyldopa through microwave basic hydrolysis 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2014-04-16 | — | — | CN | disclosed |
| CN-102911072-A | Method for preparing methyldopa by directly hydrolyzing 5-methyl-5-(3,4-dimethoxybenzyl)hydantoin with acid | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-102911072-A | Method for preparing methyldopa by directly hydrolyzing 5-methyl-5-(3,4-dimethoxybenzyl)hydantoin with acid | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-102775319-A | Method for preparing methyldopa through microwave basic hydrolysis 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2012-11-14 | — | — | CN | disclosed |
| CN-102775319-A | Method for preparing methyldopa through microwave basic hydrolysis 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin | ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD | 2012-11-14 | — | — | CN | disclosed |
| US-7666977-B2 | Poly(carbonate-co-urea) copolymers and melt transesterification method of preparing these copolymers | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2010-02-23 | — | — | US | disclosed |
| US-7557175-B2 | Poly(carbonate-co-urea) copolymers and melt transesterification method of preparing these copolymers | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2009-07-07 | — | — | US | disclosed |
| WO-2008136842-A1 | POLY( CARBONATE-CO-UREA) COPOLYMERS | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008136841-A1 | POLY(CARBONATE-CO-UREA) COPOLYMERS AND MELT TRANSESTERIFICATION METHOD OF PREPARING THESE COPOLYMERS | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-11-13 | — | — | WO | disclosed |
| US-20080275206-A1 | POLY(CARBONATE-CO-UREA) COPOLYMERS AND MELT TRANSESTERIFICATION METHOD OF PREPARING THESE COPOLYMERS | GENERAL ELECTRIC COMPANY (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080275209-A1 | POLY(CARBONATE-CO-UREA) COPOLYMERS AND MELT TRANSESTERIFICATION METHOD OF PREPARING THESE COPOLYMERS | GENERAL ELECTRIC COMPANY (US) | 2008-11-06 | — | — | US | disclosed |