SCHEMBL7104749

SCHEMBL7104749

CC1(Cc2ccc(Cl)c(Cl)c2)NC(=O)NC1=O

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 10/20 0.46
MMP2 P08253 6/20 0.46
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ADAMTS4 O75173 3/20 0.42
MMP14 P50281 1/20 0.42
MAOB P27338 1/20 0.41
ALDH1A1 P00352 1/20 0.40
MMP13 P45452 2/20 0.40
ADAM17 P78536 4/20 0.39
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
IDO1 P14902 1/20 0.38
MMP3 P08254 1/20 0.38
MMP12 P39900 1/20 0.38
DAO P14920 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9422803 1.00 ADAMTS5 (0.46) ADAMTS5MMP2SMN1; SMN2NPSR1ADAMTS4
SCHEMBL2893907 0.76 SMN1; SMN2 (0.52) MMP2SMN1; SMN2NPSR1MMP14ALDH1A1
SCHEMBL7097777 0.75 ALDH1A1 (0.60) ADAMTS5MMP2SMN1; SMN2NPSR1ALDH1A1
SCHEMBL15972776 0.75 ALDH1A1 (0.60) ADAMTS5MMP2SMN1; SMN2NPSR1ALDH1A1
SCHEMBL1108470 0.75 MMP2 (0.46) ADAMTS5MMP2SMN1; SMN2NPSR1ADAMTS4
SCHEMBL5182781 0.74 ALDH1A1 (0.46) ADAMTS5MMP2SMN1; SMN2NPSR1MMP14
SCHEMBL5182263 0.74 ALDH1A1 (0.46) ADAMTS5MMP2SMN1; SMN2NPSR1MMP14
SCHEMBL4560949 0.74 ALDH1A1 (0.46) SMN1; SMN2NPSR1ALDH1A1CYP3A4CYP2D6
SCHEMBL10576223 0.74 ALDH1A1 (0.46) SMN1; SMN2NPSR1ALDH1A1CYP3A4CYP2D6
SCHEMBL2893747 0.74 ALDH1A1 (0.46) SMN1; SMN2NPSR1ALDH1A1CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973724-B1 NOVEL PROCESS FOR THE PREPARATION OF (+/-)3- (3,4-DICHLOROPHENYL)-2- DIMETHYLAMINO-2-METHYLPROPAN-1-OL OR CERICLAMINE (INN) PARKE DAVIS (FR) 2003-10-01 EP disclosed
US-6121491-A Process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-OL or cericlamine (INN) WARNER-LAMBERT COMPANY (US) 2000-09-19 US disclosed
US-5348980-A Antihistamines, antiallergens INSTITUTE DE RECHERCHE JOUVEINAL (FR) 1994-09-20 US disclosed
US-5326878-A Salt formation with enantiomorph of A-methylbenzylamine JOUVEINAL SA (FR) 1994-07-05 US disclosed