SCHEMBL28964176

SCHEMBL28964176

Cc1ccc(N=Cc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 5/20 0.60
PTGS1 P23219 2/20 0.60
ALDH1A1 P00352 3/20 0.57
CA2 P00918 4/20 0.53
CA12 O43570 1/20 0.53
CA9 Q16790 1/20 0.53
MAPT P10636 4/20 0.51
CA1 P00915 3/20 0.46
CYP1A1 P04798 1/20 0.46
CYP1B1 Q16678 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
KDM4E B2RXH2 2/20 0.46
MEN1 O00255 1/20 0.46
TP53 P04637 1/20 0.46
THRB P10828 1/20 0.46
ALOX15 P16050 1/20 0.46
MAPK1 P28482 1/20 0.46
KMT2A Q03164 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22299941 0.85 PTGS2 (0.64) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL12633723 0.84 ALDH1A1 (0.74) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL20186922 0.84 ALDH1A1 (0.74) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL255410 0.84 ALDH1A1 (0.74) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL11557679 0.84 ALDH1A1 (0.74) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL11588746 0.84 ALDH1A1 (0.74) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL27622892 0.84 CA2 (0.64) PTGS2PTGS1ALDH1A1CA2CA12
SCHEMBL7793269 0.83 NPC1 (0.68) PTGS2PTGS1ALDH1A1MAPTCYP1A1
SCHEMBL7793264 0.83 NPC1 (0.68) PTGS2PTGS1ALDH1A1MAPTCYP1A1
SCHEMBL11409007 0.81 PTGS2 (0.59) PTGS2PTGS1ALDH1A1CA2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115745808-B Method for preparing secondary amine compound by catalyzing reduction of imine compound 延安大学 2024-04-30 CN disclosed
CN-115745808-A Method for preparing secondary amine compound by catalyzing reduction of imine compound 延安大学 2023-03-07 CN disclosed