Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Uracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL8235 | 0.84 | — | — | |
| Uracil SCHEMBL3798527 | 0.84 | CRBN (1.00) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL11607890 | 0.84 | — | — | |
| Uracil SCHEMBL5089507 | 0.84 | — | — | |
| Uracil SCHEMBL28426792 | 0.82 | CRBN (0.85) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL28867999 | 0.82 | CRBN (0.85) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL8767625 | 0.82 | — | — | |
| Uracil SCHEMBL2557975 | 0.82 | — | — | |
| Uracil SCHEMBL4664232 | 0.82 | CRBN (0.94) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL21385227 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115996638-A | Substituted N-phenyluracils and salts thereof and their use as herbicidal agents | 拜耳股份有限公司 | 2023-04-21 | — | — | CN | disclosed |