SCHEMBL29009203

SCHEMBL29009203

COC(=O)C1=C(O)C(c2ccc(F)cc2)NC1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
GAA P10253 1/20 0.42
MAPT P10636 2/20 0.40
TP53 P04637 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
TDP1 Q9NUW8 2/20 0.40
RXFP1 Q9HBX9 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
MITF O75030 1/20 0.39
ALOX15 P16050 1/20 0.39
KLF5 Q13887 1/20 0.39
CACNA1F O60840 1/20 0.38
CACNA1D Q01668 1/20 0.38
CACNA1S Q13698 1/20 0.38
CACNA1C Q13936 1/20 0.38
LMNA P02545 1/20 0.37
GLA P06280 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29009182 0.88 CA12 (0.43) MEN1KMT2AGAATP53KDM4E
SCHEMBL29009205 0.86 LMNA (0.48) MEN1KMT2AGAATP53SLC6A3
SCHEMBL29009201 0.86 ALDH1A1 (0.49) MEN1KMT2AGAATP53KDM4E
SCHEMBL29009154 0.86 GAA (0.42) MEN1KMT2AGAAMAPTTP53
SCHEMBL4238229 0.85 KMT2A (0.51) MEN1KMT2AALDH1A1ALOX15LMNA
SCHEMBL29009185 0.72 ALDH1A1 (0.50) MEN1KMT2AGAATP53KDM4E
SCHEMBL29009158 0.72 LMNA (0.49) MEN1KMT2AGAATP53SLC6A3
SCHEMBL21250244 0.72 HTR7 (0.45) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL21247502 0.72 SLC6A4 (0.44) MEN1KMT2AGAAMAPTTP53
SCHEMBL4508050 0.70 GAA (0.47) MEN1KMT2AGAAMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116217458-A 2-carbonyl-5-phenylpyrrole compound, preparation method, application and derivative thereof, and pharmaceutical composition 湖北民族大学 2023-06-06 CN disclosed