Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455188 | 0.78 | CES2 (0.50) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| SCHEMBL19191141 | 0.77 | CES2 (0.48) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| SCHEMBL585346 | 0.77 | CES2 (0.59) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| SCHEMBL13488558 | 0.75 | ALDH1A1 (0.48) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| SCHEMBL9620186 | 0.75 | CES2 (0.47) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| 2-Picolinic Acid SCHEMBL2148120 | 0.75 | LMNA (0.80) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| SCHEMBL3257574 | 0.75 | RAB9A (0.54) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| 2-Picolinic Acid SCHEMBL29038806 | 0.75 | LMNA (0.71) | LMNAL3MBTL1NAPRTP4HTMCES2 | |
| SCHEMBL9461486 | 0.75 | — | — | |
| SCHEMBL23340688 | 0.74 | LMNA (0.65) | LMNAL3MBTL1NAPRTP4HTMCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046804-B1 | Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2-yl]methyl} phosphonate used in the synthesis of himbacine analogs | MERCK SHARP & DOHME (US) | 2015-07-15 | — | — | EP | disclosed |
| US-8329905-B2 | Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate | MERCK SHARP & DOHME CORP. (US) | 2012-12-11 | — | — | US | disclosed |
| CN-101511852-B | Synthesis of diethyl { [5'' (3-fluorophenyl) -pyridin-2-yl ] methyl } phosphonate used in the synthesis of Himbacine analogs | SCHERING CORPORTAION | 2012-10-03 | — | — | CN | disclosed |
| US-20100137597-A1 | SYNTHESIS Of DIETHYLPHOSPHONATE | SCHERING CORPORATION | 2010-06-03 | — | — | US | disclosed |
| US-7687631-B2 | Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate | SCHERING CORPORATION (US) | 2010-03-30 | — | — | US | disclosed |
| CN-101511852-A | Synthesis of diethyl { [ 5' (3-fluorophenyl) -pyridin-2-yl ] methyl } phosphonate used in the Synthesis of Himbacine analogs | SCHERING CORP (US) | 2009-08-19 | — | — | CN | disclosed |
| EP-2046804-A1 | SYNTHESIS OF DIETHYL{ I5\" (3 -FLUOROPHENYL) -PYRIDINE-2-YL] METHYL} PHOSPHONATE USED IN THE SYNTHESIS OF HIMBACINE ANALOGS | SCHERING CORPORATION (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008005348-A1 | SYNTHESIS OF DIETHYL{ I5' (3 -FLUOROPHENYL) -PYRIDINE-2-YL] METHYL} PHOSPHONATE USED IN THE SYNTHESIS OF HIMBACINE ANALOGS | SCHERING CORPORATION (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20080004449-A1 | Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate | TOPROL ACQUISITION LLC | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004449-A1 | Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate | F2, F2R, PTAFR | LMNA 394/4885L3MBTL1 452/4885NAPRT 2267/4885 |
| US-20100137597-A1 | SYNTHESIS Of DIETHYLPHOSPHONATE | F2, PTAFR, TBXA2R | LMNA 336/4885L3MBTL1 638/4885NAPRT 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.