Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21001335 | 0.87 | KMO (0.58) | DHODHADORA3SCN10ASCN9AKMO | |
| Potassium SCHEMBL29961825 | 0.86 | DHODH (0.57) | DHODHADORA3SCN10ASCN9AKMO | |
| SCHEMBL29020178 | 0.86 | DHODH (0.57) | DHODHADORA3SCN10ASCN9AKMO | |
| Potassium Ion SCHEMBL29020190 | 0.83 | KMO (0.46) | DHODHADORA3SCN9AKMO | |
| Potassium Ion SCHEMBL29020126 | 0.82 | KMO (0.50) | DHODHADORA3SCN9AKMO | |
| Potassium Ion SCHEMBL28802979 | 0.81 | KMO (0.51) | DHODHADORA3KMO | |
| SCHEMBL21001230 | 0.78 | CFTR (0.47) | DHODHADORA3SCN10ASCN9ASCN2A | |
| SCHEMBL21058652 | 0.78 | DHODH (0.49) | DHODHADORA3SCN10ACHRNA7ACP1 | |
| SCHEMBL21001686 | 0.76 | AHR (0.50) | DHODHADORA3SCN10ASCN9ASCN2A | |
| SCHEMBL21001374 | 0.76 | AHR (0.69) | DHODHADORA3SCN10ASCN9ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093400-B | AhR inhibitor, application and preparation method thereof | 北京华森英诺生物科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-115093400-A | AhR inhibitor and application and preparation method thereof | 重庆华森制药股份有限公司 | 2022-09-23 | — | — | CN | disclosed |