Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 9/20 | 0.36 |
| ▸ | JAK3 | P52333 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910850 | 0.92 | MAPT (0.39) | SYKMAPTHSD17B10RXFP1 | |
| SCHEMBL2909504 | 0.86 | SYK (0.41) | PDCD1CD274SYKMTOR | |
| SCHEMBL2909862 | 0.84 | GSK3B (0.38) | SYKMAPTTP53HSD17B10 | |
| SCHEMBL2910038 | 0.70 | SYK (0.39) | SYK | |
| SCHEMBL2907636 | 0.70 | PDE4A (0.41) | PIK3CDPIK3R1PIK3CAMAPTTP53 | |
| SCHEMBL2902820 | 0.66 | KMT2A (0.34) | PIK3CDPIK3R1PIK3CATP53HSD17B10 | |
| SCHEMBL2908814 | 0.66 | KMT2A (0.34) | PIK3CDPIK3R1PIK3CATP53HSD17B10 | |
| SCHEMBL2901841 | 0.64 | VCP (0.43) | — | |
| SCHEMBL2901839 | 0.64 | VCP (0.43) | — | |
| SCHEMBL2906226 | 0.63 | CCNT1 (0.41) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | claimed |