Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9226775 | 0.90 | L3MBTL1 (0.58) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL18309270 | 0.90 | L3MBTL1 (0.60) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL9214705 | 0.87 | LMNA (0.61) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL254754 | 0.85 | ALDH1A1 (0.54) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL22500372 | 0.85 | L3MBTL1 (0.60) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL10511897 | 0.85 | L3MBTL1 (0.44) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL18309273 | 0.84 | L3MBTL1 (0.55) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL21879697 | 0.83 | CYP1A2 (0.44) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL74286 | 0.83 | L3MBTL1 (0.48) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL12250772 | 0.83 | L3MBTL1 (0.48) | L3MBTL1KMT2AMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135560-A1 | GEM-DISUBSTITUTED PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2023-05-04 | — | — | US | disclosed |
| US-20230135560-A1 | GEM-DISUBSTITUTED PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2023-05-04 | — | — | US | disclosed |
| US-11566015-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2023-01-31 | — | — | US | disclosed |
| WO-2022149617-A1 | COMPOUND LIBRARY | 中外製薬株式会社 | 2022-07-14 | — | — | WO | disclosed |
| US-20210238164-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2021-08-05 | — | — | US | disclosed |
| US-20210059798-A1 | SHADE MATCHING DENTAL COMPOSITE | BRINGLEY JOSEPH F (US) | 2021-03-04 | — | — | US | disclosed |
| US-20210002254-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2021-01-07 | — | — | US | disclosed |
| US-10766877-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20200216415-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2020-07-09 | — | — | US | disclosed |
| US-10604507-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-03-31 | — | — | US | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| WO-2010003026-A1 | METHODS FOR EXTENSIVE DARK CURING BASED ON VISIBLE-LIGHT INITIATED, CONTROLLED RADICAL POLYMERIZATION | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009058843-A2 | DENTAL COMPOSITIONS AND INITIATOR SYSTEMS WITH COLOR-STABLE AMINE ELECTRON DONORS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2009-05-07 | — | — | WO | disclosed |
| CN-101170985-A | Hardenable antimicrobial dental compositions and methods | 3M INNOVATIVE PROPERTIES CO (US) | 2008-04-30 | — | — | CN | disclosed |
| US-20080009498-A1 | Phosphodiesterase inhibitors and nitric oxide donors, compositions and methods of use | NITROMED, INC. (US) | 2008-01-10 | — | — | US | disclosed |
| EP-1578377-A1 | COMPOSITIONS INCLUDING POLYMERIZABLE BISPHOSPHONIC ACIDS AND METHODS | 3M Innovative Properties Company (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1459132-A1 | MULTIPHOTON PHOTOSENSITIZATION SYSTEM | 3M Innovative Properties Company (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2004060327-A1 | COMPOSITIONS INCLUDING POLYMERIZABLE BISPHOSPHONIC ACIDS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2003058346-A1 | MULTIPHOTON PHOTOSENSITIZATION SYSTEM | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566015-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | L3MBTL1 4237/4885KMT2A 1341/4885MEN1 644/4885 |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | HTR6, GAP43, HTR5A | L3MBTL1 4493/4885KMT2A 2847/4885MEN1 4080/4885 |
| US-20210238164-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | MC3R, MC1R, MC2R | L3MBTL1 4237/4885KMT2A 1341/4885MEN1 644/4885 |
| US-10604507-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | L3MBTL1 4237/4885KMT2A 1341/4885MEN1 644/4885 |
| US-20080009498-A1 | Phosphodiesterase inhibitors and nitric oxide donors, compositions and methods of use | PDE3A, PDE3B, PDE2A | L3MBTL1 4601/4885KMT2A 3848/4885MEN1 2960/4885 |
| US-20230135560-A1 | GEM-DISUBSTITUTED PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | MC1R, MC3R, MC2R | L3MBTL1 4621/4885KMT2A 1137/4885MEN1 920/4885 |
| US-20210002254-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | MC3R, MC1R, MC2R | L3MBTL1 4237/4885KMT2A 1341/4885MEN1 644/4885 |
| US-10766877-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | L3MBTL1 4237/4885KMT2A 1341/4885MEN1 644/4885 |
| US-20200216415-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | MC3R, MC1R, MC2R | L3MBTL1 4237/4885KMT2A 1341/4885MEN1 644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.