SCHEMBL3411071

SCHEMBL3411071

CN(C)CC(=C=O)c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 2/20 0.42
GAA P10253 1/20 0.41
ALDH1A1 P00352 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
NPC1 O15118 1/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
CYP1A2 P05177 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
ALOX12 P18054 1/20 0.40
CYP2C19 P33261 1/20 0.40
CES2 O00748 2/20 0.39
CES1 P23141 2/20 0.39
POLB P06746 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
LSS P48449 1/20 0.38
GSK3B P49841 1/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5185723 0.81 MAOA (0.41) ALDH1A1L3MBTL1NPC1MAOAMAOB
SCHEMBL289811 0.81 EGFR (0.50) ALDH1A1NPC1MAOAMAOBMAPT
SCHEMBL5489563 0.80 HPGD (0.45) GAAALDH1A1MAOAMAOBMAPT
SCHEMBL290340 0.79 CES2 (0.46) GAAALDH1A1MAOAMAOBCYP1A2
SCHEMBL933985 0.78 NAPRT (0.46) GAAALDH1A1L3MBTL1NPC1MAPT
SCHEMBL5774143 0.78 HTT (0.40) ALDH1A1L3MBTL1CYP1A2HPGDCYP2C19
SCHEMBL5772527 0.77 LSS (0.44) NPC1CES2CES1LSSGSK3B
SCHEMBL1257917 0.76 MAPK1 (0.47) GAAALDH1A1HPGDCES2CES1
SCHEMBL5776317 0.76 ALDH1A1 (0.49) ALDH1A1NPC1MAPT
SCHEMBL1651006 0.75 HCAR2 (0.46) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2257541-A1 MODULATORS FOR AMYLOID BETA F. Hoffmann-La Roche AG (CH) 2010-12-08 EP disclosed
WO-2009103652-A1 MODULATORS FOR AMYLOID BETA F. HOFFMANN-LA ROCHE AG (CH) 2009-08-27 WO disclosed