Pregomisin

Pregomisin

SCHEMBL29045386

COc1cc(C[C@@H](C)[C@@H](C)Cc2cc(O)c(OC)c(OC)c2)cc(O)c1OC

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 6/20 0.62
ALOX12 P18054 6/20 0.62
FOS P01100 2/20 0.62
TTR P02766 2/20 0.62
JUN P05412 2/20 0.62
NR3C1 P04150 2/20 0.62
HSD17B1 P14061 2/20 0.62
HSD17B2 P37059 2/20 0.62
TUBB1 Q9H4B7 5/20 0.50
TUBB4A P04350 4/20 0.50
TUBB P07437 4/20 0.50
TUBA3C P0DPH7 4/20 0.50
TUBA1B P68363 4/20 0.50
TUBA4A P68366 4/20 0.50
TUBB4B P68371 4/20 0.50
TUBB3 Q13509 4/20 0.50
TUBB2A Q13885 4/20 0.50
TUBB8 Q3ZCM7 4/20 0.50
TUBA3E Q6PEY2 4/20 0.50
TUBA1A Q71U36 4/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31554242 0.91 ALOX15 (0.76) ALOX15ALOX12FOSTTRJUN
SCHEMBL10998613 0.87 PTGS2 (0.59) ALOX15ALOX12FOSTTRJUN
SCHEMBL6733483 0.82 GAA (0.78) ALOX15ALOX12FOSTTRJUN
SCHEMBL8372028 0.79 PTGS2 (0.73) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL30079962 0.79 TUBB4A (0.74) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL29286367 0.79 TUBB4A (0.74) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL3364601 0.79 TUBB4A (0.54) ALOX15TUBB1TUBB4ATUBBTUBA3C
SCHEMBL3566176 0.78 HTR2A (0.53) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL4962257 0.77 PTGS2 (0.48) ALOX15ALOX12FOSTTRJUN
Dihydroguaiaretic Acid SCHEMBL9087980 0.76 FOS (1.00) ALOX15ALOX12FOSTTRJUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119876062-A Polypeptide for catalyzing lignan cyclization, encoding gene, preparation method and application 中国医学科学院药用植物研究所 2025-04-25 CN claimed
CN-116606832-A Dibenzylbutane lignan oxymethyl transferase and application thereof 中国医学科学院药用植物研究所 2023-08-18 CN claimed
CN-116478949-A Lignan oxymethyl transferase and use thereof 中国医学科学院药用植物研究所 2023-07-25 CN claimed
EP-4201205-A2 USE OF NATURAL COMPOUNDS AS ACARICIDES Gonella Invent Societa' A Responsabilita' Limitata Semplificata (IT) 2023-06-28 EP claimed
US-20220265747-A1 Compositions, Methods, and Medical Compositions for Treatment of and Maintaining the Health of the Liver UNIGEN, INC. (US) 2022-08-25 US claimed
WO-2026104851-A1 PHARMACEUTICAL COMPOSITIONS Apollo AP10 Limited (GB) 2026-05-21 WO disclosed
US-20250144164-A1 COMPOSITIONS, METHODS, AND MEDICAL COMPOSITIONS FOR TREATMENT OF AND MAINTAINING THE HEALTH OF THE LIVER UNIGEN, INC. (US) 2025-05-08 US disclosed
CN-119876062-A Polypeptide for catalyzing lignan cyclization, encoding gene, preparation method and application 中国医学科学院药用植物研究所 2025-04-25 CN disclosed
CN-119859620-A Polypeptide for catalyzing hydroxylation of lignans, encoding gene, preparation method and application 中国医学科学院药用植物研究所 2025-04-22 CN disclosed
CN-115003291-B Use and composition for improving the oral bioavailability of hydroxytyrosol based on polyphenols 生物探索有限公司 2024-10-29 CN disclosed
CN-118695854-A Food-related particles, production method and production device 努利希尔有限公司 2024-09-24 CN disclosed
CN-118384212-A Schisandra chinensis extract F3 component, preparation method thereof and application thereof in non-alcoholic fatty liver 中国医学科学院药用植物研究所 2024-07-26 CN disclosed
US-20230079480-A1 STABLE NON-AQUEOUS COMPOSITIONS OF FUNCTIONAL INGREDIENTS AND METHODS OF MAKING THE SAME Nulixir Inc. 2023-03-16 US disclosed
US-20230081296-A1 STABLE NON-AQUEOUS COMPOSITIONS OF PLANTS EXTRACTS AND METHODS OF MAKING THE SAME Nulixir Inc. 2023-03-16 US disclosed
US-20230082651-A1 STABLE AQUEOUS COMPOSITIONS OF PLANTS EXTRACTS AND METHODS OF MAKING THE SAME Nulixir Inc. 2023-03-16 US disclosed
EP-4110309-A1 USES AND COMPOSITIONS BASED ON POLYPHENOLS FOR IMPROVING THE ORAL BIOAVAILABILITY OF HYDROXYTYROSOL Biosearch S.A. (ES) 2023-01-04 EP disclosed
CN-115003291-A Use and composition based on polyphenols for increasing the oral bioavailability of hydroxytyrosol 生物探索有限公司 2022-09-02 CN disclosed
US-20220265747-A1 Compositions, Methods, and Medical Compositions for Treatment of and Maintaining the Health of the Liver UNIGEN, INC. (US) 2022-08-25 US disclosed
US-11331359-B2 Compositions, methods, and medical compositions for treatment of and maintaining the health of the liver UNIGEN, INC. (US) 2022-05-17 US disclosed
CN-108138199-B Plants containing low copy number of RI gene 克鲁德简普森花卉公司 2022-01-21 CN disclosed