Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29047632 | 0.84 | ERN1 (0.47) | LMNAPPARGALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL29047611 | 0.82 | TDP1 (0.49) | LMNAPPARGALDH1A1PTGS2CA1 | |
| SCHEMBL29047606 | 0.82 | ALDH1A1 (0.43) | LMNAPPARGALDH1A1CA1CA2 | |
| SCHEMBL11745047 | 0.80 | ALDH1A1 (0.50) | LMNAPPARGALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL29047573 | 0.78 | CA1 (0.40) | LMNAPPARGALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL28134701 | 0.78 | LMNA (0.45) | LMNAPPARGALDH1A1PTGS2HTT | |
| SCHEMBL27899666 | 0.78 | LMNA (0.45) | LMNAPPARGALDH1A1PTGS2HTT | |
| SCHEMBL29047615 | 0.77 | SLC22A12 (0.39) | LMNAALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL29047589 | 0.77 | ERN1 (0.47) | LMNAALDH1A1PTGS2HTTSMN1; SMN2 | |
| SCHEMBL29047638 | 0.77 | POLB (0.56) | LMNAPPARGALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108947931-B | Thiazole amide compound, preparation method thereof, pharmaceutical composition and application | 中国科学院上海有机化学研究所 | 2023-07-07 | — | — | CN | disclosed |