Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646471 | 0.82 | POLB (0.59) | POLBLMNAALDH1A1MAPTPPARG | |
| SCHEMBL9681604 | 0.78 | ENPP2 (0.61) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL29047698 | 0.77 | LMNA (0.43) | POLBLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL29047606 | 0.77 | ALDH1A1 (0.43) | LMNAALDH1A1PPARGGAAMEN1 | |
| SCHEMBL29047632 | 0.76 | ERN1 (0.47) | LMNAALDH1A1KDM4EMAPTPPARG | |
| SCHEMBL24534671 | 0.76 | MEN1 (0.74) | POLBLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL29047673 | 0.75 | ALDH1A1 (0.52) | POLBLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL29047611 | 0.74 | TDP1 (0.49) | LMNAALDH1A1MAPTPPARGGAA | |
| SCHEMBL11745047 | 0.73 | ALDH1A1 (0.50) | POLBLMNAALDH1A1PPARGGAA | |
| SCHEMBL30996945 | 0.72 | RAB9A (0.50) | POLBLMNAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108947931-B | Thiazole amide compound, preparation method thereof, pharmaceutical composition and application | 中国科学院上海有机化学研究所 | 2023-07-07 | — | — | CN | disclosed |