Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CDC42 | P60953 | 1/20 | 0.36 |
| ▸ | RAC1 | P63000 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911974 | 0.91 | KDM4E (0.37) | GPR35SMN1; SMN2AKR1C3AKR1C2PTGS2 | |
| SCHEMBL4040809 | 0.90 | GPR35 (0.42) | GPR35SMN1; SMN2AKR1C3AKR1C2CYP1A2 | |
| SCHEMBL27616643 | 0.82 | MAPT (0.40) | SMN1; SMN2PTGS2KDM4EALDH1A1HPGD | |
| SCHEMBL6550172 | 0.77 | SMN1; SMN2 (0.59) | GPR35SMN1; SMN2AKR1C3AKR1C2PTGS2 | |
| SCHEMBL2904869 | 0.74 | MAPT (0.41) | SMN1; SMN2CYP1A2ALDH1A1HPGDPOLB | |
| SCHEMBL2914394 | 0.74 | ALOX5 (0.37) | GPR35SMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL2911971 | 0.73 | RAB9A (0.44) | GPR35SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2914392 | 0.71 | CACNA1H (0.47) | SMN1; SMN2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL4044393 | 0.70 | GPR35 (0.39) | GPR35SMN1; SMN2AKR1C3AKR1C2TSHR | |
| SCHEMBL7240393 | 0.70 | SMN1; SMN2 (0.77) | GPR35SMN1; SMN2AKR1C3AKR1C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481679-B1 | ANTIDEPRESSANT | TAKEDA PHARMACEUTICAL (JP) | 2010-08-25 | — | — | EP | claimed |
| EP-1323716-B1 | PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS | TAKEDA PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | claimed |
| EP-1323716-B1 | PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS | TAKEDA PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | disclosed |