Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057418 | 0.80 | ALDH1A1 (0.61) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL7128494 | 0.77 | ALDH1A1 (0.55) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL15264904 | 0.76 | LMNA (0.46) | ALDH1A1LMNAL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL2456684 | 0.74 | HTR7 (0.77) | ALDH1A1LMNAHTR1BHTR7L3MBTL1 | |
| SCHEMBL30862623 | 0.74 | HTR7 (0.77) | ALDH1A1LMNAHTR1BHTR7L3MBTL1 | |
| SCHEMBL791938 | 0.74 | HTR1A (0.60) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL1592409 | 0.73 | CA12 (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL11419578 | 0.73 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL13916263 | 0.72 | POLB (0.49) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Guaiactamine SCHEMBL25797 | 0.71 | ALDH1A1 (0.78) | ALDH1A1LMNAHTR1DHTR1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918055-A1 | Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol] | EGIS GYOGYSZERGYAR RT. (HU) | 1999-05-26 | — | — | EP | claimed |
| EP-1756057-B1 | PROCESS FOR THE PREPARATION OF CARVEDILOL | CIPLA LTD (IN) | 2010-08-04 | — | — | EP | disclosed |
| US-7705163-B2 | Process for the preparation of carvedilol | CIPLA LIMITED (IN) | 2010-04-27 | — | — | US | disclosed |
| US-20080234492-A1 | Process for the Preparation of Carvedilol | CIPLA LIMITED (IN) | 2008-09-25 | — | — | US | disclosed |
| EP-1756057-A1 | PROCESS FOR THE PREPARATION OF CARVEDILOL | Cipla Ltd. (IN) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005113502-A1 | PROCESS FOR THE PREPARATION OF CARVEDILOL | CIPLA LIMITED (IN) | 2005-12-01 | — | — | WO | disclosed |
| EP-0918055-A1 | Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol] | EGIS GYOGYSZERGYAR RT. (HU) | 1999-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234492-A1 | Process for the Preparation of Carvedilol | ADRB2, ADRB3, ADRB1 | HTR1A 1503/4885ADRA1D 17/4885ADRA1A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.