SCHEMBL29080255

SCHEMBL29080255

C=CCC#Cc1ccc(F)cc1

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.37
DRD2 P14416 3/20 0.33
GRM5 P41594 3/20 0.33
GRIN2B Q13224 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM1 P11229 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HCAR2 Q8TDS4 1/20 0.32
LMNA P02545 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
THPO P40225 1/20 0.30
APP P05067 1/20 0.30
HAO1 Q9UJM8 1/20 0.30
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29080282 0.79 KCNH2 (0.44) FFAR1GRM5CHRM2CHRM1SMN1; SMN2
SCHEMBL29080275 0.79 LMNA (0.42) DRD2GRM5CHRM2CHRM1LMNA
SCHEMBL29080261 0.79 CYP2A6 (0.39) LMNAMAOAMAOB
SCHEMBL29080306 0.79 PYCR1 (0.37) LMNACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL29080277 0.79 KIF11 (0.40) SMN1; SMN2LMNAMAOB
SCHEMBL2117815 0.78 CYP1A2 (0.52) LMNACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL29080268 0.77 CA12 (0.42) GRM5CHRM2CHRM1CYP3A4
SCHEMBL18375968 0.71 GRM5 (0.36) FFAR1GRM5APP
SCHEMBL103643 0.71 MMP2 (0.47) FFAR1DRD2GRM5GRIN2BHCAR2
SCHEMBL7573145 0.71 CYP2C19 (0.60) FFAR1DRD2GRM5GRIN2BCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115490567-A 1, 3-eneyne compound synthesized by copper catalysis and synthesis method thereof 西安交通大学 2022-12-20 CN disclosed