Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L1CAM | P32004 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL4755324 | 0.84 | L1CAM (0.61) | L1CAMMEN1KMT2AGAARAB9A | |
| Potassium Ion SCHEMBL11808886 | 0.84 | L1CAM (0.61) | L1CAMMEN1KMT2AGAARAB9A | |
| Potassium Ion SCHEMBL9365529 | 0.82 | HDAC6 (0.55) | L1CAMMEN1KMT2AGAAMAPT | |
| Potassium Ion SCHEMBL4872287 | 0.81 | ALDH1A1 (0.70) | GAAALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL29123185 | 0.78 | CA1 (0.67) | MEN1KMT2AGAARAB9ANPC1 | |
| SCHEMBL2834498 | 0.74 | ALDH1A1 (0.60) | MEN1KMT2AGAARAB9ANPC1 | |
| SCHEMBL7667888 | 0.72 | GFER (0.60) | MEN1KMT2AGAARAB9ANPC1 | |
| SCHEMBL29202850 | 0.71 | GFER (0.65) | MEN1KMT2AGAAALDH1A1UBE2N | |
| SCHEMBL14266881 | 0.70 | GFER (0.58) | MEN1KMT2AGAAALDH1A1UBE2N | |
| SCHEMBL10567622 | 0.69 | ALDH1A1 (0.68) | MEN1KMT2AGAARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117186028-A | Thiadiazole amide compound containing sulfonate structure, and preparation method and application thereof | 贵州大学 | 2023-12-08 | — | — | CN | disclosed |