Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.52 |
| ▸ | L1CAM | P32004 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11808886 | 1.00 | L1CAM (0.61) | L1CAMRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| Potassium Ion SCHEMBL29123377 | 0.84 | L1CAM (0.56) | L1CAMRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL400890 | 0.82 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6967578 | 0.81 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL11298577 | 0.81 | RAB9A (0.75) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA | |
| Potassium Ion SCHEMBL4872287 | 0.81 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL12324391 | 0.80 | RAB9A (0.82) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6967575 | 0.79 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL9825195 | 0.79 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL37273 | 0.78 | ALDH1A1 (0.68) | RAB9ANPC1SMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157407-A2 | THIADIAZOLE, OXADIAZOLE AND TRIAZOLE DERIVATIVES FOR TREATING LEUKEMIA | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-12-24 | — | — | WO | disclosed |