Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22624739 | 0.79 | APP (0.65) | CXCR2CXCR1MAPTALDH1A1GAA | |
| SCHEMBL10494719 | 0.79 | CA2 (0.62) | CA2CA12CA9MAPTALDH1A1 | |
| SCHEMBL8820451 | 0.78 | CA2 (0.61) | CA2CA12CA9CXCR2CXCR1 | |
| SCHEMBL8883682 | 0.78 | KMT2A (0.47) | CA2CA12CA9HPGDKMT2A | |
| SCHEMBL3009938 | 0.76 | GPR35 (0.53) | CA2CA12CA9ALDH1A1GAA | |
| SCHEMBL3034692 | 0.76 | TSHR (0.53) | CA2ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL8012475 | 0.76 | GAA (0.56) | CA2CA12CA9MAPTALDH1A1 | |
| Water SCHEMBL3012136 | 0.75 | GPR35 (0.51) | CA2CA12CA9ALDH1A1GAA | |
| SCHEMBL3009943 | 0.75 | TSHR (0.51) | CA2ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL7808995 | 0.75 | GPR35 (0.51) | CA2CA12CA9ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1617816-B1 | NANOPARTICULATE MELOXICAN FORMULATIONS | ELAN PHARMA INT LTD (IE) | 2009-05-13 | — | — | EP | claimed |
| US-6187343-B1 | MULTISTAGE MIXING, MICRONIZATION, ROTATION AND SEPARATION | BINDECOR SOCIEDAD ANONIMA (UY) | 2001-02-13 | — | — | US | claimed |
| EP-2066301-B1 | INJECTABLE PHARMACEUTICAL NIMESULIDE SOLUTIONS | PHARMATEX ITALIA SRL (IT) | 2010-08-25 | — | — | EP | disclosed |
| US-20100035868-A1 | METHODS OF TREATMENT OF UTERINE PATHOLOGICAL CONDITIONS | MEDICAL RESEARCH COUNCIL (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20090258947-A1 | NOVEL LOW DOSE PHARMACEUTICAL COMPOSITIONS COMPRISING NIMESULIDE, PREPARATION AND USE THEREOF | PANACEA BIOTEC LIMITED (IN) | 2009-10-15 | — | — | US | disclosed |
| EP-2066301-A1 | INJECTABLE PHARMACEUTICAL NIMESULIDE SOLUTIONS | Pharmatex Italia Srl (IT) | 2009-06-10 | — | — | EP | disclosed |
| EP-2015740-A1 | NOVEL LOW DOSE PHARMACEUTICAL COMPOSITIONS COMPRISING NIMESULIDE, PREPARATION AND USE THEREOF | Panacea Biotec Ltd. (IN) | 2009-01-21 | — | — | EP | disclosed |
| WO-2008034819-A1 | INJECTABLE PHARMACEUTICAL NIMESULIDE SOLUTIONS | PHARMATEX ITALIA SRL (IT) | 2008-03-27 | — | — | WO | disclosed |
| EP-1902705-A1 | Injectable pharmaceutical nimesulide solutions | Pharmatex Italia Srl (IT) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007122637-A1 | NOVEL LOW DOSE PHARMACEUTICAL COMPOSITIONS COMPRISING NIMESULIDE, PREPARATION AND USE THEREOF | PANACEA BIOTEC LTD. (IN) | 2007-11-01 | — | — | WO | disclosed |
| EP-1562570-A4 | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH NIMESULIDE | SINAI SCHOOL MEDICINE (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-0937709-A1 | Nimesulide micronised salts | Helsinn Healthcare S.A. (CH) | 1999-08-25 | — | — | EP | disclosed |
| EP-0714386-B1 | WATER-SOLUBLE NIMESULIDE SALT, AND USES THEREOF FOR THE TREATMENT OF INFLAMMATIONS | EUROPHARMACEUTICALS SA (BE) | 1999-03-10 | — | — | EP | disclosed |
| EP-0889724-A1 | COX-2 SELECTIVE INHIBITORS FOR MANAGING LABOUR AND UTERINE CONTRACTIONS | RPMS TECHNOLOGY LIMITED (GB) | 1999-01-13 | — | — | EP | disclosed |
| US-5837735-A | NIMESULIDE AS ANTIINFLAMMATORY AGENTS | HELSINN HEALTHCARE S.A. (CH) | 1998-11-17 | — | — | US | disclosed |
| US-5756546-A | WATER SOLUBLE SALT OF NIMESULIDE AND LYSINE | PIROTTE BERNARD (BE) | 1998-05-26 | — | — | US | disclosed |
| WO-1997031631-A1 | COX-2 SELECTIVE INHIBITORS FOR MANAGING LABOUR AND UTERINE CONTRACTIONS | RPMS TECHNOLOGY LIMITED (GB) | 1997-09-04 | — | — | WO | disclosed |
| EP-0782855-A1 | ANTIINFLAMMATORY AGENT FOR EXTERNAL USE | Helsinn Healthcare S.A. (CH) | 1997-07-09 | — | — | EP | disclosed |
| EP-0714386-A1 | WATER-SOLUBLE NIMESULIDE SALT, AND USES THEREOF FOR THE TREATMENT OF INFLAMMATIONS | EUROPHARMACEUTICALS S.A. (BE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995034533-A1 | WATER-SOLUBLE NIMESULIDE SALT, AND USES THEREOF FOR THE TREATMENT OF INFLAMMATIONS | EUROPHARMACEUTICALS S.A. (BE) | 1995-12-21 | — | — | WO | disclosed |