SCHEMBL29128779

SCHEMBL29128779

CC(=O)Nc1ccc(-c2cc(C(=O)O)cc(C(=O)O)c2)cn1

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTK2 Q05397 1/20 0.51
TDO2 P48775 1/20 0.51
PIK3CD O00329 1/20 0.49
PIK3CG P48736 1/20 0.49
KMT2A Q03164 1/20 0.47
CYP1A2 P05177 1/20 0.47
GAA P10253 1/20 0.47
HCAR3 P49019 3/20 0.45
NSD2 O96028 1/20 0.45
ADORA3 P0DMS8 1/20 0.43
ABCB1 P08183 1/20 0.43
ABCC1 P33527 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28118455 0.88 PTK2 (0.54) PTK2PIK3CDPIK3CGKMT2ACYP1A2
SCHEMBL28294579 0.87 KMO (0.52) TDO2PIK3CDPIK3CGGAA
SCHEMBL30338494 0.81 PTK2 (0.57) PTK2PIK3CDPIK3CGKMT2ACYP1A2
SCHEMBL82675 0.80 HCAR3 (0.68) PTK2KMT2ACYP1A2GAAHCAR3
SCHEMBL10195598 0.78 PTK2 (0.57) PTK2TDO2PIK3CDPIK3CGKMT2A
SCHEMBL17317003 0.76 TDO2 (0.58) PTK2TDO2PIK3CDPIK3CGKMT2A
SCHEMBL22975369 0.76 PTK2 (0.56) PTK2TDO2PIK3CDPIK3CGKMT2A
SCHEMBL22975368 0.76 PTK2 (0.56) PTK2TDO2PIK3CDPIK3CGKMT2A
SCHEMBL17114304 0.75 P4HA1 (0.59)
SCHEMBL22575346 0.75 CSNK2A1 (0.51) PTK2TDO2PIK3CDPIK3CGCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117049961-A Yeast dehydrogenase inhibitor derivative and synthesis method thereof 苏州君叶生物医药科技有限公司 2023-11-14 CN disclosed