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SCHEMBL2913465

SCHEMBL2913465

Cc1ccc(C2c3c(C)c(NC(=O)c4ccc5c(c4)OCO5)c(C)c(C)c3OC2(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 13/20 0.47
▸ RAB9A P51151 13/20 0.47
▸ SMN1; SMN2 Q16637 7/20 0.47
▸ MAPT P10636 6/20 0.47
▸ HPGD P15428 4/20 0.45
▸ ALDH1A1 P00352 4/20 0.45
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ KDM4E B2RXH2 2/20 0.45
▸ USP2 O75604 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ TP53 P04637 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ PKM P14618 3/20 0.44
▸ NFKB1 P19838 1/20 0.43
▸ NFKB2 Q00653 1/20 0.43
▸ RELA Q04206 1/20 0.43
▸ PTGS2 P35354 1/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2943035 0.91 MEN1 (0.43) NPC1RAB9ASMN1; SMN2MAPTHPGD
SCHEMBL27598139 0.90 SMN1; SMN2 (0.42) NPC1RAB9ASMN1; SMN2MAPTHPGD
SCHEMBL2912943 0.82 PKM (0.49) NPC1RAB9ASMN1; SMN2MAPTHPGD
SCHEMBL2913757 0.81 RAB9A (0.47) NPC1RAB9ASMN1; SMN2MAPTHPGD
SCHEMBL4088002 0.79 CYP2C19 (0.36) ALDH1A1CYP3A4CYP2C9
SCHEMBL2947678 0.79 KDM4E (0.39) NPC1RAB9AMAPTHPGDALDH1A1
Hydrochloric Acid SCHEMBL2914481 0.78 LMNA (0.45) NPC1RAB9ASMN1; SMN2MAPTHPGD
SCHEMBL27597976 0.76 MAPT (0.37) NPC1RAB9ASMN1; SMN2MAPTHPGD
SCHEMBL2911504 0.74 KDM4E (0.42) NPC1RAB9AMAPTALDH1A1MEN1
SCHEMBL2905201 0.74 LMNA (0.36) NPC1RAB9ASMN1; SMN2MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1481679-B1 ANTIDEPRESSANT TAKEDA PHARMACEUTICAL (JP) 2010-08-25 — — EP disclosed
US-7750037-B2 Antidepressant TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-07-06 — — US disclosed
EP-1323716-B1 PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS TAKEDA PHARMACEUTICAL (JP) 2009-01-14 — — EP disclosed
US-20090012081-A1 Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) 2009-01-08 — — US disclosed
US-7456162-B2 Benzofuran derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-11-25 — — US disclosed
US-20060241168-A1 Antidepressant OHKAWA SHIGENORI 2006-10-26 — — US disclosed
US-7101867-B2 Benzofuran derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-09-05 — — US disclosed
US-20050187238-A1 Benzofuran derivatives, their production and use OHKAWA SHIGENORI (JP) 2005-08-25 — — US disclosed
US-20050148650-A1 Antidepressant TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-07-07 — — US disclosed
EP-1481679-A1 ANTIDEPRESSANT Takeda Chemical Industries, Ltd. (JP) 2004-12-01 — — EP disclosed
EP-1136477-B1 BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-03-10 — — EP disclosed
US-20040034049-A1 Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-19 — — US disclosed
EP-1323716-A1 PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS Takeda Chemical Industries, Ltd. (JP) 2003-07-02 — — EP disclosed
US-6479536-B1 Benzofuran derivatives, process for the preparation of the same and uses thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-11-12 — — US disclosed
US-20020160996-A1 Benzofuran derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2002-10-31 — — US disclosed
EP-1136477-A1 BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF Takeda Chemical Industries, Ltd. (JP) 2001-09-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050148650-A1 Antidepressant AKT1S1, AKT1, AKT2 NPC1 2368/4885RAB9A 1372/4885SMN1; SMN2 3766/4885
US-20060241168-A1 Antidepressant AKT1S1, AKT1, AKT2 NPC1 2368/4885RAB9A 1372/4885SMN1; SMN2 3766/4885
US-20090012081-A1 Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells NES, MKI67, CCNO NPC1 2467/4885RAB9A 2438/4885SMN1; SMN2 376/4885
US-20050187238-A1 Benzofuran derivatives, their production and use WDR1, WDR82, CBR1 NPC1 835/4885RAB9A 2549/4885SMN1; SMN2 54/4885
US-20040034049-A1 Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells NES, HAT1, PROX1 NPC1 2378/4885RAB9A 2371/4885SMN1; SMN2 528/4885
US-20020160996-A1 Benzofuran derivatives, their production and use PARK7, WDR1, WHR1 NPC1 428/4885RAB9A 2580/4885SMN1; SMN2 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.