Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 10/20 | 0.42 |
| ▸ | RAB9A | P51151 | 10/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913465 | 0.91 | NPC1 (0.47) | MEN1KMT2ANPC1RAB9APKM | |
| SCHEMBL27598139 | 0.87 | SMN1; SMN2 (0.42) | MEN1KMT2ANPC1RAB9APKM | |
| SCHEMBL2912995 | 0.84 | SMN1; SMN2 (0.39) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2905201 | 0.84 | LMNA (0.36) | KMT2ANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2905197 | 0.83 | KDM4E (0.35) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL2911427 | 0.83 | LMNA (0.40) | KMT2ANPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL2910674 | 0.83 | PKM (0.43) | MEN1KMT2ANPC1RAB9APKM | |
| SCHEMBL2909184 | 0.83 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL2913347 | 0.82 | RAB9A (0.42) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2905121 | 0.82 | RAB9A (0.37) | KMT2ANPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481679-B1 | ANTIDEPRESSANT | TAKEDA PHARMACEUTICAL (JP) | 2010-08-25 | — | — | EP | disclosed |
| US-7750037-B2 | Antidepressant | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-06 | — | — | US | disclosed |
| US-7491529-B2 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| EP-1323716-B1 | PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS | TAKEDA PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-20090012081-A1 | Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| US-7456162-B2 | Benzofuran derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-25 | — | — | US | disclosed |
| US-7309761-B2 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-7189814-B2 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7166282-B2 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7157247-B2 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20020132252-A1 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. | 2002-09-19 | — | — | US | disclosed |
| US-20020127576-A1 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. | 2002-09-12 | — | — | US | disclosed |
| US-20020123463-A1 | Secreted and transmembrane polypeptides and nucliec acids encodiing the same | GENENTECH, INC. | 2002-09-05 | — | — | US | disclosed |
| US-20020072496-A1 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. | 2002-06-13 | — | — | US | disclosed |
| US-20020072067-A1 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. | 2002-06-13 | — | — | US | disclosed |
| US-20020072092-A1 | Secreted and transmembrane polypeptides and nucleic acids encoding the same | GENENTECH, INC. | 2002-06-13 | — | — | US | disclosed |
| EP-1210418-A1 | SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME | Genentech Inc. (US) | 2002-06-05 | — | — | EP | disclosed |
| EP-1136477-A1 | BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000073454-A1 | SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME | GENENTECH, INC. (US) | 2000-12-07 | — | — | WO | disclosed |
| WO-1999063088-A2 | MEMBRANE-BOUND PROTEINS AND NUCLEIC ACIDS ENCODING THE SAME | GENENTECH, INC. (US) | 1999-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012081-A1 | Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells | NES, MKI67, CCNO | MEN1 2906/4885KMT2A 1061/4885NPC1 2467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.