Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29302948 | 0.96 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL29879837 | 0.96 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL29305488 | 0.82 | REN (0.36) | ALDH1A1MEN1KMT2AMAPTHSD11B1 | |
| SCHEMBL11211269 | 0.81 | L3MBTL1 (0.45) | ALDH1A1MEN1KMT2AHTTNPSR1 | |
| SCHEMBL29879558 | 0.77 | HSD11B1 (0.42) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29302947 | 0.77 | HSD11B1 (0.42) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL24738866 | 0.76 | HTR2C (0.48) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL11077633 | 0.76 | ADAM17 (0.44) | KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL29878836 | 0.76 | HTR2C (0.48) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| Lithium Ion SCHEMBL29136989 | 0.75 | HSD11B1 (0.40) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |