SCHEMBL29138724

SCHEMBL29138724

C#CCNn1ccc(=O)[nH]c1=O

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 3/20 0.44
PKM P14618 1/20 0.37
DDB1 Q16531 1/20 0.37
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
DUT P33316 5/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3752207 0.76 CRBN (0.40) CRBNPKMDDB1ALDH1A1LMNA
SCHEMBL8933242 0.74 CRBN (0.41) CRBNPKMDDB1ALDH1A1LMNA
SCHEMBL3541014 0.74 CRBN (0.54) CRBNPKMDDB1ALDH1A1LMNA
SCHEMBL9763767 0.73 CRBN (0.42) CRBNPKMDUT
SCHEMBL25430771 0.72 GPR84 (0.44) CRBN
SCHEMBL29138705 0.71 MAPK1 (0.41) ALDH1A1LMNA
SCHEMBL5604080 0.71 PKM (0.40) CRBNPKMDDB1ALDH1A1LMNA
SCHEMBL2181554 0.70 CRBN (0.54) CRBNPKMDDB1ALDH1A1LMNA
SCHEMBL22144561 0.69 PKM (0.47) CRBNPKMDDB1ALDH1A1LMNA
SCHEMBL7632468 0.68 CRBN (0.47) CRBNPKMDDB1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038963-A1 OLIGONUCLEOTIDES CONTAINING MULTIPLE LIGANDS AND/OR LIPIDS ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
WO-2025111430-A1 CHEMICAL MODIFICATIONS IN mRNA POLY(A) TAIL PRIME MEDICINE, INC. (US) 2025-05-30 WO disclosed
WO-2025080995-A1 PHARMACEUTICAL AGENT-INTEGRIN LIGAND CONJUGATES FOR MUSCLE DELIVERY ADARX PHARMACEUTICALS, INC. (US) 2025-04-17 WO disclosed
CN-115867670-A Base-modified nucleotides as substrates for TDT-based enzyme nucleic acids 伊鲁米纳新加坡有限公司 2023-03-28 CN disclosed