Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DUT | P33316 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181554 | 0.78 | CRBN (0.54) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL8933239 | 0.76 | CRBN (0.47) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL30479438 | 0.76 | CRBN (0.47) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL11389897 | 0.75 | CRBN (0.46) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL9019445 | 0.74 | CRBN (0.44) | CRBNDDB1ALDH1A1LMNADUT | |
| SCHEMBL29138724 | 0.74 | CRBN (0.44) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL7030201 | 0.72 | CRBN (0.43) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL28414334 | 0.72 | CRBN (0.47) | CRBNDDB1ALDH1A1LMNADUT | |
| SCHEMBL12099167 | 0.71 | CRBN (0.42) | CRBNDDB1PKMALDH1A1LMNA | |
| SCHEMBL9763767 | 0.71 | CRBN (0.42) | CRBNPKMDUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200362337-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-11-19 | — | — | US | disclosed |
| US-9856230-B2 | Enzyme inhibitors | UNIVERSITY OF SUNDERLAND (GB) | 2018-01-02 | — | — | US | disclosed |
| US-20150322035-A1 | Enzyme Inhibitors | UNIVERSITY OF SUNDERLAND (GB) | 2015-11-12 | — | — | US | disclosed |
| CN-101003512-B | Method for preparing methylamino uracil | SHANGHAI CHEMICAL REAGENT RES INST | 2011-03-16 | — | — | CN | disclosed |
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
| CN-101003512-A | Method for preparing methylamino uracil | SHANGHAI INST OF CHEMICAL AGEN (CN) | 2007-07-25 | — | — | CN | disclosed |
| US-20070043000-A1 | Immunosuppresive effects of pteridine derivatives | 4 AZA BIOSCIENCE NV (BE) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322035-A1 | Enzyme Inhibitors | TXNRD3, TXNRD2, TXNRD1 | CRBN 2179/4885DDB1 1254/4885PKM 1247/4885 |
| US-20070043000-A1 | Immunosuppresive effects of pteridine derivatives | TPMT, FKBP5, RRP15 | CRBN 2691/4885DDB1 896/4885PKM 892/4885 |
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | CRBN 3578/4885DDB1 4446/4885PKM 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.