Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30694298 | 1.00 | GPR183 (0.40) | GPR183NR1H2NR1H3SCD5CYP3A4 | |
| SCHEMBL31568643 | 0.93 | CYP3A4 (0.44) | GPR183NR1H2NR1H3SCD5CYP3A4 | |
| SCHEMBL30423051 | 0.81 | CYP11B2 (0.41) | GPR183NR1H2NR1H3SCD5CYP3A4 | |
| SCHEMBL30423454 | 0.81 | CYP11B2 (0.43) | GPR183NR1H2NR1H3SCD5CYP3A4 | |
| SCHEMBL25202645 | 0.81 | CYP11B2 (0.41) | GPR183NR1H2NR1H3SCD5CYP3A4 | |
| SCHEMBL25212034 | 0.81 | CYP11B2 (0.43) | GPR183NR1H2NR1H3SCD5CYP3A4 | |
| SCHEMBL31437071 | 0.80 | RET (0.45) | GPR183NR1H2NR1H3CYP11B2GPR119 | |
| SCHEMBL24571655 | 0.80 | RET (0.45) | GPR183NR1H2NR1H3CYP11B2GPR119 | |
| SCHEMBL30702599 | 0.80 | SIRT6 (0.35) | CYP3A4CYP2C9CYP1A2TSHRCYP2C19 | |
| SCHEMBL31568634 | 0.79 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023241598-A1 | AROMATIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF IN PREPARATION OF ESTROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-12-21 | — | — | WO | disclosed |
| CN-117229286-A | Aromatic compound, preparation method thereof and application thereof in preparation of estrogen receptor degradation agent | 海创药业股份有限公司 | 2023-12-15 | — | — | CN | disclosed |