Sugi Predict

Sugi Predict / Compounds / SCHEMBL2915295

SCHEMBL2915295

SCHEMBL2915295

CC(C)(C)OC(=O)N1CCN(O)CC1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60
▸ HPGD P15428 1/20 0.50
▸ EPHX2 P34913 1/20 0.49
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ RECQL P46063 1/20 0.47
▸ EPHX1 P07099 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ POLB P06746 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ ATM Q13315 1/20 0.44
▸ GPR119 Q8TDV5 1/20 0.44
▸ NR1H2 P55055 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL698803 0.91 USP2 (0.69) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL18294 0.91 USP2 (0.69) USP2SMN1; SMN2HPGDEPHX2MEN1
Pyridine SCHEMBL28289324 0.85 GPR119 (0.48) USP2SMN1; SMN2POLBGPR119
SCHEMBL16612394 0.84 USP2 (0.62) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL27388627 0.84 USP2 (0.62) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL2223924 0.83 USP2 (0.60) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL6061822 0.83 USP2 (0.60) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL2430769 0.83 USP2 (0.60) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL8874348 0.83 USP2 (0.60) USP2SMN1; SMN2HPGDEPHX2MEN1
SCHEMBL17344112 0.83 USP2 (0.60) USP2SMN1; SMN2HPGDEPHX2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240165259-A1 BIOORTHOGONAL REACTION SUITABLE FOR CLICK/UNCLICK APPLICATIONS DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-05-23 — — US disclosed
EP-4320073-A1 BIOORTHOGONAL REACTION SUITABLE FOR CLICK/UNCLICK APPLICATIONS Dana-Farber Cancer Institute, Inc. (US) 2024-02-14 — — EP disclosed
CN-117337267-A Bioorthogonal reactions suitable for click/click cancellation applications 达纳－法伯癌症研究所公司 2024-01-02 — — CN disclosed
EP-3689868-B1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS INC (US) 2023-09-27 — — EP disclosed
US-20230132298-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS, LLC 2023-04-27 — — US disclosed
US-11578087-B2 Oxaborole esters and uses thereof ANACOR PHARMACEUTICALS, INC. (US) 2023-02-14 — — US disclosed
WO-2022216616-A1 BIOORTHOGONAL REACTION SUITABLE FOR CLICK/UNCLICK APPLICATIONS DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-10-13 — — WO disclosed
US-20210101916-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS, INC. 2021-04-08 — — US disclosed
US-20210032214-A1 COMPOUNDS FOR BINDING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 SRX CARDIO, LLC 2021-02-04 — — US disclosed
WO-2020235582-A1 PREVENTIVE AND/OR THERAPEUTIC AGENT FOR MOTOR NEURON DISEASE グリーン・テック株式会社 (JP) 2020-11-26 — — WO disclosed
EP-3689868-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas Operations, Inc. (US) 2020-08-05 — — EP disclosed
CN-101772735-B Radiation-sensitive resin composition JSR CORP 2012-09-26 — — CN disclosed
EP-1591443-B1 PYRAZOLE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2010-08-25 — — EP disclosed
CN-101772735-A Radiation sensitive resin composition JSR CORP 2010-07-07 — — CN disclosed
US-7622471-B2 Pyrazole derivatives having a pyridazine and pyridine functionality DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2009-11-24 — — US disclosed
US-20060128685-A1 Pyrazole derivative DAIICHI PHARMACEUTICAL CO., LTD., (JP) 2006-06-15 — — US disclosed
EP-1591443-A1 PYRAZOLE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-11-02 — — EP disclosed
US-4247549-A Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity ICI AMERICAS INC. (US) 1981-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060128685-A1 Pyrazole derivative PTGS1, PTGS2, PTGER1 USP2 3881/4885SMN1; SMN2 3778/4885HPGD 18/4885
US-20210032214-A1 COMPOUNDS FOR BINDING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 PCSK9, PCSK6, PCSK7 USP2 2975/4885SMN1; SMN2 4099/4885HPGD 2190/4885
US-20230132298-A1 OXABOROLE ESTERS AND USES THEREOF OXA1L, HSD17B12, OXER1 USP2 3643/4885SMN1; SMN2 442/4885HPGD 2258/4885
US-20210101916-A1 OXABOROLE ESTERS AND USES THEREOF OXA1L, HSD17B12, OXER1 USP2 3643/4885SMN1; SMN2 442/4885HPGD 2258/4885
US-11578087-B2 Oxaborole esters and uses thereof OXA1L, HSD17B12, OXER1 USP2 3643/4885SMN1; SMN2 442/4885HPGD 2258/4885
US-20240165259-A1 BIOORTHOGONAL REACTION SUITABLE FOR CLICK/UNCLICK APPLICATIONS CILK1, SYMPK, DCK USP2 165/4885SMN1; SMN2 3553/4885HPGD 2446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.