Acridine

Acridine

SCHEMBL29156872

O.O.c1ccc2nc3ccccc3cc2c1.c1ccc2nc3ccccc3cc2c1

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.94
HTR3A known ✓ P46098 1/20 0.62
MEN1 known ✓ O00255 1/20 0.48
CACNA1B known ✓ Q00975 1/20 0.48
ALDH1A1 P00352 4/20 0.94
MAPT P10636 3/20 0.94
HPGD P15428 3/20 0.94
GLA P06280 2/20 0.94
NQO2 P16083 2/20 0.60
KDM4E B2RXH2 3/20 0.54
GAA P10253 3/20 0.54
KMT2A Q03164 3/20 0.54
NPC1 O15118 2/20 0.54
POLB P06746 2/20 0.54
LMNA P02545 1/20 0.54
PTBP1 P26599 1/20 0.54
RAB9A P51151 1/20 0.54
RCE1 Q9Y256 1/20 0.54
TDP1 Q9NUW8 1/20 0.50
STAT3 P40763 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acridine SCHEMBL5192723 1.00 ALDH1A1 (0.94) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL27536790 1.00 ALDH1A1 (0.94) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL27503478 1.00 ALDH1A1 (0.94) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL4972293 0.97 ALDH1A1 (1.00) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL3045498 0.97 ALDH1A1 (1.00) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL8339 0.97 ALDH1A1 (1.00) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL1772714 0.97 ALDH1A1 (1.00) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL29352289 0.97 ALDH1A1 (1.00) ALDH1A1MAPTHPGDGLAACHE
Anthracene SCHEMBL9879830 0.94 MAPT (0.94) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL618814 0.94 ALDH1A1 (0.94) ALDH1A1MAPTHPGDGLAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112673259-B IGFBP-7 based preeclampsia prediction 豪夫迈·罗氏有限公司 2024-11-22 CN disclosed
CN-112236434-B Polycyclic compound and organic light emitting device including the same 株式会社LG化学 2024-02-23 CN disclosed