Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30725455 | 1.00 | MAPT (0.50) | MAPTKDM4EALDH1A1RAB9ANPSR1 | |
| SCHEMBL29174594 | 0.78 | ALDH1A1 (0.38) | MAPTKDM4EALDH1A1RAB9ANPSR1 | |
| SCHEMBL30725525 | 0.78 | ALDH1A1 (0.38) | MAPTKDM4EALDH1A1RAB9ANPSR1 | |
| SCHEMBL31006834 | 0.77 | CCNB2 (0.42) | MAPTKDM4EALDH1A1RAB9ANPSR1 | |
| SCHEMBL30725488 | 0.77 | KMT2A (0.44) | MAPTALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL29174582 | 0.77 | KMT2A (0.44) | MAPTALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL30940969 | 0.76 | MAPT (0.44) | MAPTKDM4EALDH1A1RAB9ANPSR1 | |
| SCHEMBL29174697 | 0.74 | PKM (0.44) | ALDH1A1CYP2C19ABL1BCRPKM | |
| SCHEMBL30919726 | 0.74 | HTT (0.46) | MAPTALDH1A1RAB9ANPC1CYP2C9 | |
| SCHEMBL6039811 | 0.72 | HTR6 (0.56) | CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117430589-A | 2-aminopyrimidine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-01-23 | — | — | CN | disclosed |